Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q(10)

Statins are efficient cholesterol-lowering medicines utilized worldwide. However, 10% of patients suffer from adverse effects specially related to skeletal muscle function. Pro- or anti-oxidant effects of statins have been reported. Here we hypothesized that statins induce muscle mitochondrial oxida...

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Detalles Bibliográficos
Autores principales: Busanello, Estela N. B., Marques, Ana C., Lander, Noelia, de Oliveira, Diogo N., Catharino, Rodrigo R., Oliveira, Helena C. F., Vercesi, Anibal E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380726/
https://www.ncbi.nlm.nih.gov/pubmed/28424622
http://dx.doi.org/10.3389/fphar.2017.00185

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