Cargando…

Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis

BACKGROUND: Systemic sclerosis (SSc) is a chronic disease with microvascular damage. Nailfold capillaroscopy is a non-invasive method used for evaluating capillaries in SSc. Its findings could be related to the internal organ involvement and SSc course. In this study, we aimed to determine the assoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Shenavandeh, Saeedeh, Haghighi, Mahyar Yousefipour, Nazarinia, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380768/
https://www.ncbi.nlm.nih.gov/pubmed/28386138
http://dx.doi.org/10.5114/reum.2017.66683
_version_ 1782519811854565376
author Shenavandeh, Saeedeh
Haghighi, Mahyar Yousefipour
Nazarinia, Mohammad Ali
author_facet Shenavandeh, Saeedeh
Haghighi, Mahyar Yousefipour
Nazarinia, Mohammad Ali
author_sort Shenavandeh, Saeedeh
collection PubMed
description BACKGROUND: Systemic sclerosis (SSc) is a chronic disease with microvascular damage. Nailfold capillaroscopy is a non-invasive method used for evaluating capillaries in SSc. Its findings could be related to the internal organ involvement and SSc course. In this study, we aimed to determine the association of the capillaroscopic patterns of nailfold capillaries with the disease subtypes of SSc, disease duration, and clinical manifestations. MATERIAL AND METHODS: Seventy patients with SSc (15 cases with diffuse cutaneous SSc [DcSSc] and 55 patients with limited SSc [LcSSc]) were studied. The patients were classified into early and intermediate/late DcSSc and LcSSc regarding their disease duration. The capillaroscopy findings were classified into normal, ‘early’, ‘active’ and ‘late’ scleroderma patterns, and ‘non-specific’ changes. The association of the nailfold capillaroscopy changes and their components with clinical manifestations was also studied. RESULTS: We studied 15 DcSSc and 55 LcSSc patients. No association was found between the patterns of capillaroscopic changes and these subtypes. There were 8 early DcSSc, 7 intermediate/late DcSSc, 34 early LcSSc, and 21 intermediate/late LcSSc patients. In patients with LcSSc, the ‘early’ scleroderma pattern of capillaroscopy was associated with early disease based on duration. We found a direct association between some capillary components and some clinical findings. Also, some capillaroscopic components had an inverse association with some clinical manifestations. CONCLUSIONS: We found no association between the patterns of capillaroscopy and SSc subtypes; early scleroderma pattern of capillaroscopy was significantly associated with early LcSSc, compatible with the slower course of the disease in LcSSc. Subtle changes, capillary elongation, and capillary tortuosity had an inverse association with clinical manifestations and might be considered as good prognostic factors.
format Online
Article
Text
id pubmed-5380768
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie
record_format MEDLINE/PubMed
spelling pubmed-53807682017-04-06 Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis Shenavandeh, Saeedeh Haghighi, Mahyar Yousefipour Nazarinia, Mohammad Ali Reumatologia Original Paper BACKGROUND: Systemic sclerosis (SSc) is a chronic disease with microvascular damage. Nailfold capillaroscopy is a non-invasive method used for evaluating capillaries in SSc. Its findings could be related to the internal organ involvement and SSc course. In this study, we aimed to determine the association of the capillaroscopic patterns of nailfold capillaries with the disease subtypes of SSc, disease duration, and clinical manifestations. MATERIAL AND METHODS: Seventy patients with SSc (15 cases with diffuse cutaneous SSc [DcSSc] and 55 patients with limited SSc [LcSSc]) were studied. The patients were classified into early and intermediate/late DcSSc and LcSSc regarding their disease duration. The capillaroscopy findings were classified into normal, ‘early’, ‘active’ and ‘late’ scleroderma patterns, and ‘non-specific’ changes. The association of the nailfold capillaroscopy changes and their components with clinical manifestations was also studied. RESULTS: We studied 15 DcSSc and 55 LcSSc patients. No association was found between the patterns of capillaroscopic changes and these subtypes. There were 8 early DcSSc, 7 intermediate/late DcSSc, 34 early LcSSc, and 21 intermediate/late LcSSc patients. In patients with LcSSc, the ‘early’ scleroderma pattern of capillaroscopy was associated with early disease based on duration. We found a direct association between some capillary components and some clinical findings. Also, some capillaroscopic components had an inverse association with some clinical manifestations. CONCLUSIONS: We found no association between the patterns of capillaroscopy and SSc subtypes; early scleroderma pattern of capillaroscopy was significantly associated with early LcSSc, compatible with the slower course of the disease in LcSSc. Subtle changes, capillary elongation, and capillary tortuosity had an inverse association with clinical manifestations and might be considered as good prognostic factors. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2017-03-22 2017 /pmc/articles/PMC5380768/ /pubmed/28386138 http://dx.doi.org/10.5114/reum.2017.66683 Text en Copyright: © 2017 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Shenavandeh, Saeedeh
Haghighi, Mahyar Yousefipour
Nazarinia, Mohammad Ali
Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
title Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
title_full Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
title_fullStr Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
title_full_unstemmed Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
title_short Nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
title_sort nailfold digital capillaroscopic findings in patients with diffuse and limited cutaneous systemic sclerosis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380768/
https://www.ncbi.nlm.nih.gov/pubmed/28386138
http://dx.doi.org/10.5114/reum.2017.66683
work_keys_str_mv AT shenavandehsaeedeh nailfolddigitalcapillaroscopicfindingsinpatientswithdiffuseandlimitedcutaneoussystemicsclerosis
AT haghighimahyaryousefipour nailfolddigitalcapillaroscopicfindingsinpatientswithdiffuseandlimitedcutaneoussystemicsclerosis
AT nazariniamohammadali nailfolddigitalcapillaroscopicfindingsinpatientswithdiffuseandlimitedcutaneoussystemicsclerosis