FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch

Bruck Syndrome is a connective tissue disease associated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein 65 (FKBP65/FKBP10). However, the functional relationship between LH2 and FKBP65 remains unclear. Here, we postulated that peptidyl prolyl isomerase (PPIase...

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Detalles Bibliográficos
Autores principales: Chen, Yulong, Terajima, Masahiko, Banerjee, Priyam, Guo, Houfu, Liu, Xin, Yu, Jiang, Yamauchi, Mitsuo, Kurie, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380960/
https://www.ncbi.nlm.nih.gov/pubmed/28378777
http://dx.doi.org/10.1038/srep46021

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