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Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary
This study describes a novel microfluidic-based method for the synthesis of hydrogel microsprings that are capable of encapsulating various functional materials. A continuous flow of alginate pre-gel solution can spontaneously form a hydrogel microspring by anisotropic gelation around the bevel-tip...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380988/ https://www.ncbi.nlm.nih.gov/pubmed/28378803 http://dx.doi.org/10.1038/srep45987 |
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author | Yoshida, Koki Onoe, Hiroaki |
author_facet | Yoshida, Koki Onoe, Hiroaki |
author_sort | Yoshida, Koki |
collection | PubMed |
description | This study describes a novel microfluidic-based method for the synthesis of hydrogel microsprings that are capable of encapsulating various functional materials. A continuous flow of alginate pre-gel solution can spontaneously form a hydrogel microspring by anisotropic gelation around the bevel-tip of the capillary. This technique allows fabrication of hydrogel microsprings using only simple capillaries and syringe pumps, while their complex compartmentalization characterized by a laminar flow inside the capillary can contribute to the optimization of the microspring internal structure and functionality. Encapsulation of several functional materials including magnetic-responsive nanoparticles or cell dispersed collagen for tissue scaffold was demonstrated to functionalize the microsprings. Our core-shell hydrogel microsprings have immense potential for application in a number of fields, including biological/chemical microsensors, biocompatible soft robots/microactuators, drug release, self-assembly of 3D structures and tissue engineering. |
format | Online Article Text |
id | pubmed-5380988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53809882017-04-07 Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary Yoshida, Koki Onoe, Hiroaki Sci Rep Article This study describes a novel microfluidic-based method for the synthesis of hydrogel microsprings that are capable of encapsulating various functional materials. A continuous flow of alginate pre-gel solution can spontaneously form a hydrogel microspring by anisotropic gelation around the bevel-tip of the capillary. This technique allows fabrication of hydrogel microsprings using only simple capillaries and syringe pumps, while their complex compartmentalization characterized by a laminar flow inside the capillary can contribute to the optimization of the microspring internal structure and functionality. Encapsulation of several functional materials including magnetic-responsive nanoparticles or cell dispersed collagen for tissue scaffold was demonstrated to functionalize the microsprings. Our core-shell hydrogel microsprings have immense potential for application in a number of fields, including biological/chemical microsensors, biocompatible soft robots/microactuators, drug release, self-assembly of 3D structures and tissue engineering. Nature Publishing Group 2017-04-05 /pmc/articles/PMC5380988/ /pubmed/28378803 http://dx.doi.org/10.1038/srep45987 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Yoshida, Koki Onoe, Hiroaki Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
title | Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
title_full | Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
title_fullStr | Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
title_full_unstemmed | Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
title_short | Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
title_sort | functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380988/ https://www.ncbi.nlm.nih.gov/pubmed/28378803 http://dx.doi.org/10.1038/srep45987 |
work_keys_str_mv | AT yoshidakoki functionalizedcoreshellhydrogelmicrospringsbyanisotropicgelationwithbeveltipcapillary AT onoehiroaki functionalizedcoreshellhydrogelmicrospringsbyanisotropicgelationwithbeveltipcapillary |