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RUNX1 induces DNA replication independent of active DNA demethylation at SPI1 regulatory regions
BACKGROUND: SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory regions are demethylated during hematopoietic development, although how the chang...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381148/ https://www.ncbi.nlm.nih.gov/pubmed/28376714 http://dx.doi.org/10.1186/s12867-017-0087-y |