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Deployable micro-traps to sequester motile bacteria

The development of strategies to reduce the load of unwanted bacteria is a fundamental challenge in industrial processing, environmental sciences and medical applications. Here, we report a new method to sequester motile bacteria from a liquid, based on passive, deployable micro-traps that confine b...

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Detalles Bibliográficos
Autores principales: Di Giacomo, Raffaele, Krödel, Sebastian, Maresca, Bruno, Benzoni, Patrizia, Rusconi, Roberto, Stocker, Roman, Daraio, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381207/
https://www.ncbi.nlm.nih.gov/pubmed/28378786
http://dx.doi.org/10.1038/srep45897
Descripción
Sumario:The development of strategies to reduce the load of unwanted bacteria is a fundamental challenge in industrial processing, environmental sciences and medical applications. Here, we report a new method to sequester motile bacteria from a liquid, based on passive, deployable micro-traps that confine bacteria using micro-funnels that open into trapping chambers. Even in low concentrations, micro-traps afford a 70% reduction in the amount of bacteria in a liquid sample, with a potential to reach >90% as shown by modelling improved geometries. This work introduces a new approach to contain the growth of bacteria without chemical means, an advantage of particular importance given the alarming growth of pan-drug-resistant bacteria.