Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism

The patient was an 18-year-old man who developed nephrotic syndrome after a ‘wheat spider’ bite (Latrodectus mactans). Due to this atypical manifestation of latrodectism, a renal biopsy was performed showing minimal change disease. The nephrotic syndrome subsided after 1 week without specific treatm...

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Detalles Bibliográficos
Autores principales: Méndez, Gonzalo P., Enos, Daniel, Moreira, José Luis, Alvaredo, Fátima, Oddó, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Glomerulopathies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381243/
https://www.ncbi.nlm.nih.gov/pubmed/28396739
http://dx.doi.org/10.1093/ckj/sfw110
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author Méndez, Gonzalo P.
Enos, Daniel
Moreira, José Luis
Alvaredo, Fátima
Oddó, David
author_facet Méndez, Gonzalo P.
Enos, Daniel
Moreira, José Luis
Alvaredo, Fátima
Oddó, David
author_sort Méndez, Gonzalo P.
collection PubMed
description The patient was an 18-year-old man who developed nephrotic syndrome after a ‘wheat spider’ bite (Latrodectus mactans). Due to this atypical manifestation of latrodectism, a renal biopsy was performed showing minimal change disease. The nephrotic syndrome subsided after 1 week without specific treatment. This self-limited evolution suggests that the mechanism of podocyte damage was temporary and potentially mediated by a secondary mechanism of hypersensitivity or direct effect of the α-latrotoxin. The patient did not show signs of relapse in subsequent checkup. This is the first reported case of nephrotic syndrome due to a minimal change lesion secondary to latrodectism.
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spelling pubmed-53812432017-04-10 Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism Méndez, Gonzalo P. Enos, Daniel Moreira, José Luis Alvaredo, Fátima Oddó, David Clin Kidney J Glomerulopathies The patient was an 18-year-old man who developed nephrotic syndrome after a ‘wheat spider’ bite (Latrodectus mactans). Due to this atypical manifestation of latrodectism, a renal biopsy was performed showing minimal change disease. The nephrotic syndrome subsided after 1 week without specific treatment. This self-limited evolution suggests that the mechanism of podocyte damage was temporary and potentially mediated by a secondary mechanism of hypersensitivity or direct effect of the α-latrotoxin. The patient did not show signs of relapse in subsequent checkup. This is the first reported case of nephrotic syndrome due to a minimal change lesion secondary to latrodectism. Oxford University Press 2017-04 2016-12-26 /pmc/articles/PMC5381243/ /pubmed/28396739 http://dx.doi.org/10.1093/ckj/sfw110 Text en © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Glomerulopathies
Méndez, Gonzalo P.
Enos, Daniel
Moreira, José Luis
Alvaredo, Fátima
Oddó, David
Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
title Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
title_full Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
title_fullStr Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
title_full_unstemmed Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
title_short Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
title_sort nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism
topic Glomerulopathies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381243/
https://www.ncbi.nlm.nih.gov/pubmed/28396739
http://dx.doi.org/10.1093/ckj/sfw110
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