Cargando…

Association of γH2AX at Diagnosis with Chemotherapy Outcome in Patients with Breast Cancer

γH2AX plays a role in DNA damage response signaling and facilitates the repair of DNA double strand breaks. However, it remains unknown whether constitutive tumor γH2AX expression is associated with treatment outcome in patients. γH2AX status was detected in primary tumors from 24% of 826 patients w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Sherry X., Polley, Eric C., Nguyen, Dat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381256/ https://www.ncbi.nlm.nih.gov/pubmed/28382166 http://dx.doi.org/10.7150/thno.19102

Ejemplares similares

Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks
por: Rybak, Paulina, et al.
Publicado: (2016)

Genome Instability and γH2AX
por: Georgoulis, Anastasios, et al.
Publicado: (2017)

Assessment of γ-H2AX levels in circulating tumor cells from patients receiving chemotherapy
por: Garcia-Villa, Alejandra, et al.
Publicado: (2012)

γH2AX spreading linked to homology search
por: Renkawitz, Jörg, et al.
Publicado: (2013)

BCLAF1 is a radiation-induced H2AX-interacting partner involved in γH2AX-mediated regulation of apoptosis and DNA repair
por: Lee, Y Y, et al.
Publicado: (2012)

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair
por: Sone, Kenbun, et al.
Publicado: (2014)

The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age
por: Merighi, Adalberto, et al.
Publicado: (2021)

Radiosensitivity in breast cancer assessed by the histone γ-H2AX and 53BP1 foci
por: Djuzenova, Cholpon S, et al.
Publicado: (2013)

Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer
por: Nguyen, Dat, et al.
Publicado: (2020)

BRCA1 and γH2AX as independent prognostic markers in oral squamous cell carcinoma
por: Oliveira-Costa, Joao Paulo, et al.
Publicado: (2014)

Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells
por: Pustovalova, Margarita, et al.
Publicado: (2016)

Spontaneous γH2AX foci in human dermal fibroblasts in relation to proliferation activity and aging
por: Zorin, Vadim, et al.
Publicado: (2019)

Heterochromatin is refractory to γ-H2AX modification in yeast and mammals
por: Kim, Jung-Ae, et al.
Publicado: (2007)

Endogenous DNA breaks: γH2AX and the role of telomeres
por: Olive, Peggy L.
Publicado: (2009)

Generation of an alpaca-derived nanobody recognizing γ-H2AX
por: Rajan, Malini, et al.
Publicado: (2015)

Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells
por: Seo, Jungmin, et al.
Publicado: (2012)

Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication
por: Yu, Jinghua, et al.
Publicado: (2022)

γ-H2AX as a potential indicator of radiosensitivity in colorectal cancer cells
por: Kawashima, Satoshi, et al.
Publicado: (2020)

Residual γH2AX foci as an indication of lethal DNA lesions
por: Banáth, Judit P, et al.
Publicado: (2010)

Expression of γH2AX in various gastric pathologies and its association with Helicobacter pylori infection
por: XIE, CHUAN, et al.
Publicado: (2014)

γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments
por: Rawlinson, Rebecca, et al.
Publicado: (2014)

Genome-wide multi-parametric analysis of H2AX or γH2AX distributions during ionizing radiation-induced DNA damage response
por: Natale, Francesco, et al.
Publicado: (2013)

Systemic treatment and radiotherapy, breast cancer subtypes, and survival after long-term clinical follow-up
por: Yang, Sherry X., et al.
Publicado: (2019)

PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
por: Sharma, Deepti, et al.
Publicado: (2019)

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation
por: Cowell, Ian G., et al.
Publicado: (2007)

Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase
por: Hiyoshi, H, et al.
Publicado: (2012)

The γH2AX DNA damage assay from a drop of blood
por: Heylmann, Daniel, et al.
Publicado: (2016)

Study on γH2AX Expression of Lymphocytes as a Biomarker In Radiation Biodosimetry
por: Pan, Yan, et al.
Publicado: (2016)

Advantages of evaluating γH2AX induction in non-clinical drug development
por: Motoyama, Shigeki, et al.
Publicado: (2018)

Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect
por: Anglada, Teresa, et al.
Publicado: (2019)

γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers
por: Fu, Shibo, et al.
Publicado: (2012)

Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells
por: Kang, Su Jin, et al.
Publicado: (2017)

Increased γ-H2A.X Intensity in Response to Chronic Medium-Dose-Rate γ-Ray Irradiation
por: Sugihara, Takashi, et al.
Publicado: (2012)

Distinct increased outliers among 136 rectal cancer patients assessed by γH2AX
por: Kroeber, Jana, et al.
Publicado: (2015)

γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
por: Kinner, Andrea, et al.
Publicado: (2008)

DNA Damage Sensor γ-H2AX Is Increased in Preneoplastic Lesions of Hepatocellular Carcinoma
por: Matsuda, Yasunobu, et al.
Publicado: (2013)

Investigating γH2AX as a Biomarker of Radiosensitivity Using Flow Cytometry Methods
por: Beaton, Lindsay A., et al.
Publicado: (2013)

Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions
por: GUO, ZHONG, et al.
Publicado: (2015)

Super-Resolution Localization Microscopy of γ-H2AX and Heterochromatin after Folate Deficiency
por: Bach, Margund, et al.
Publicado: (2017)

Controlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear γ-H2AX possibly via iNOS induction
por: Jiang, Bo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_srunel6mur540r5b4lp38dd6o7