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Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation

The primary challenge in thermal ablation of liver tumors (e.g. hepatocellular carcinoma and hepatic colorectal cancer) is the relatively high recurrence rate (~30%) for which incomplete ablation at the periphery of the tumor is the most common reason. In an attempt to overcome this, we have develop...

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Autores principales: Park, William Keun Chan, Maxwell, Aaron Wilhelm Palmer, Frank, Victoria Elizabeth, Primmer, Michael Patrick, Collins, Scott Andrew, Baird, Grayson Luderman, Dupuy, Damian Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381263/
https://www.ncbi.nlm.nih.gov/pubmed/28382173
http://dx.doi.org/10.7150/thno.18191
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author Park, William Keun Chan
Maxwell, Aaron Wilhelm Palmer
Frank, Victoria Elizabeth
Primmer, Michael Patrick
Collins, Scott Andrew
Baird, Grayson Luderman
Dupuy, Damian Edward
author_facet Park, William Keun Chan
Maxwell, Aaron Wilhelm Palmer
Frank, Victoria Elizabeth
Primmer, Michael Patrick
Collins, Scott Andrew
Baird, Grayson Luderman
Dupuy, Damian Edward
author_sort Park, William Keun Chan
collection PubMed
description The primary challenge in thermal ablation of liver tumors (e.g. hepatocellular carcinoma and hepatic colorectal cancer) is the relatively high recurrence rate (~30%) for which incomplete ablation at the periphery of the tumor is the most common reason. In an attempt to overcome this, we have developed a novel thermal accelerant (TA) agent capable of augmenting microwave energy from a distance normally unattainable by a single microwave ablation antenna. This cesium-based block co-polymer compound transforms from a liquid to a gel at body temperature and is intrinsically visible by computed tomography. Using an agarose phantom model, herein we demonstrate that both the rate and magnitude of temperature increase during microwave ablation were significantly greater in the presence of TA when compared with controls. These results suggest robust augmentation of microwave energy, and may translate into larger ablation zone volumes within biologic tissues. Further work using in vivo techniques is necessary to confirm these findings.
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spelling pubmed-53812632017-04-05 Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation Park, William Keun Chan Maxwell, Aaron Wilhelm Palmer Frank, Victoria Elizabeth Primmer, Michael Patrick Collins, Scott Andrew Baird, Grayson Luderman Dupuy, Damian Edward Theranostics Research Paper The primary challenge in thermal ablation of liver tumors (e.g. hepatocellular carcinoma and hepatic colorectal cancer) is the relatively high recurrence rate (~30%) for which incomplete ablation at the periphery of the tumor is the most common reason. In an attempt to overcome this, we have developed a novel thermal accelerant (TA) agent capable of augmenting microwave energy from a distance normally unattainable by a single microwave ablation antenna. This cesium-based block co-polymer compound transforms from a liquid to a gel at body temperature and is intrinsically visible by computed tomography. Using an agarose phantom model, herein we demonstrate that both the rate and magnitude of temperature increase during microwave ablation were significantly greater in the presence of TA when compared with controls. These results suggest robust augmentation of microwave energy, and may translate into larger ablation zone volumes within biologic tissues. Further work using in vivo techniques is necessary to confirm these findings. Ivyspring International Publisher 2017-02-26 /pmc/articles/PMC5381263/ /pubmed/28382173 http://dx.doi.org/10.7150/thno.18191 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Park, William Keun Chan
Maxwell, Aaron Wilhelm Palmer
Frank, Victoria Elizabeth
Primmer, Michael Patrick
Collins, Scott Andrew
Baird, Grayson Luderman
Dupuy, Damian Edward
Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation
title Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation
title_full Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation
title_fullStr Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation
title_full_unstemmed Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation
title_short Evaluation of a Novel Thermal Accelerant for Augmentation of Microwave Energy during Image-guided Tumor Ablation
title_sort evaluation of a novel thermal accelerant for augmentation of microwave energy during image-guided tumor ablation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381263/
https://www.ncbi.nlm.nih.gov/pubmed/28382173
http://dx.doi.org/10.7150/thno.18191
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