Role of transient receptor potential melastatin type 7 channel in gastric cancer

Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg(2+) and Ca(2+). It contains a channel and a kinase...

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Detalles Bibliográficos
Autores principales: Kim, Byung Joo, Hong, Chansik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381434/
https://www.ncbi.nlm.nih.gov/pubmed/28462107
http://dx.doi.org/10.1016/j.imr.2016.04.004
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author Kim, Byung Joo
Hong, Chansik
author_facet Kim, Byung Joo
Hong, Chansik
author_sort Kim, Byung Joo
collection PubMed
description Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg(2+) and Ca(2+). It contains a channel and a kinase domain. Recent studies indicate that activation of TRPM7 plays an important role in the growth and survival of gastric cancer cells. In this review, we describe and discuss the findings of recent studies that have provided novel insights of the relation between TRPM7 and gastric cancer.
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spelling pubmed-53814342017-05-01 Role of transient receptor potential melastatin type 7 channel in gastric cancer Kim, Byung Joo Hong, Chansik Integr Med Res Review Article Transient receptor potential (TRP) proteins are a family of ion channels, which are responsible for a wide array of cellular functions. In particular, TRP melastatin type (TRPM) 7 is expressed everywhere and permeable to divalent cations such as Mg(2+) and Ca(2+). It contains a channel and a kinase domain. Recent studies indicate that activation of TRPM7 plays an important role in the growth and survival of gastric cancer cells. In this review, we describe and discuss the findings of recent studies that have provided novel insights of the relation between TRPM7 and gastric cancer. Elsevier 2016-06 2016-04-11 /pmc/articles/PMC5381434/ /pubmed/28462107 http://dx.doi.org/10.1016/j.imr.2016.04.004 Text en © 2016 Korea Institute of Oriental Medicine. Published by Elsevier. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Kim, Byung Joo
Hong, Chansik
Role of transient receptor potential melastatin type 7 channel in gastric cancer
title Role of transient receptor potential melastatin type 7 channel in gastric cancer
title_full Role of transient receptor potential melastatin type 7 channel in gastric cancer
title_fullStr Role of transient receptor potential melastatin type 7 channel in gastric cancer
title_full_unstemmed Role of transient receptor potential melastatin type 7 channel in gastric cancer
title_short Role of transient receptor potential melastatin type 7 channel in gastric cancer
title_sort role of transient receptor potential melastatin type 7 channel in gastric cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381434/
https://www.ncbi.nlm.nih.gov/pubmed/28462107
http://dx.doi.org/10.1016/j.imr.2016.04.004
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