Cargando…

Molecular Characterization of the Monoclonal Antibodies Composing ZMAb: A Protective Cocktail Against Ebola Virus

Ebola virus (EBOV) causes severe viral hemorrhagic fever in humans and non-human primates, with a case fatality rate of up to 88% in human outbreaks. Over the past 3 years, monoclonal antibody (mAb) cocktails have demonstrated high efficacy as treatments against EBOV infection. One such cocktail is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Audet, Jonathan, Wong, Gary, Wang, Han, Lu, Guangwen, Gao, George F., Kobinger, Gary, Qiu, Xiangguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381473/ https://www.ncbi.nlm.nih.gov/pubmed/25375093 http://dx.doi.org/10.1038/srep06881

Ejemplares similares

Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb
por: Qiu, Xiangguo, et al.
Publicado: (2013)

Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection
por: Qiu, Xiangguo, et al.
Publicado: (2012)

Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents
por: Wong, Gary, et al.
Publicado: (2014)

Characterization of a Bivalent Vaccine Capable of Inducing Protection Against Both Ebola and Cross-clade H5N1 Influenza in Mice
por: Wong, Gary, et al.
Publicado: (2015)

Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
por: Fausther-Bovendo, Hugues, et al.
Publicado: (2021)

Potent neutralizing monoclonal antibodies against Ebola virus infection
por: Zhang, Qi, et al.
Publicado: (2016)

Modeling Ebola Virus Transmission Using Ferrets
por: de La Vega, Marc-Antoine, et al.
Publicado: (2018)

Role of Key Infectivity Parameters in the Transmission of Ebola Virus Makona in Macaques
por: de La Vega, Marc Antoine, et al.
Publicado: (2021)

Can Ebola virus become endemic in the human population?
por: Wong, Gary, et al.
Publicado: (2015)

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
por: Fan, Pengfei, et al.
Publicado: (2020)

Purification and characterization of monoclonal IgG antibodies recognizing Ebola virus glycoprotein
por: Han, Baek-Sang, et al.
Publicado: (2018)

Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time
por: Wei, Haiyan, et al.
Publicado: (2017)

A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection
por: Choi, Jin Huk, et al.
Publicado: (2014)

The Cytokine Response Profile of Ebola Virus Disease in a Large Cohort of Rhesus Macaques Treated With Monoclonal Antibodies
por: Banadyga, Logan, et al.
Publicado: (2019)

Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine
por: Richardson, Jason S., et al.
Publicado: (2009)

The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development
por: Zhu, Wenjun, et al.
Publicado: (2019)

AAV-monoclonal antibody expression protects mice from Ebola virus without impeding the endogenous antibody response to heterologous challenge
por: van Lieshout, Laura P., et al.
Publicado: (2022)

NK Cells Accumulate in Infected Tissues and Contribute to Pathogenicity of Ebola Virus in Mice
por: Fausther-Bovendo, H., et al.
Publicado: (2019)

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp(™)
por: Qiu, Xiangguo, et al.
Publicado: (2014)

ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 Infection
por: Yadav, Pragya D., et al.
Publicado: (2021)

Incorporation of Ebola glycoprotein into HIV particles facilitates dendritic cell and macrophage targeting and enhances HIV-specific immune responses
por: Ao, Zhujun, et al.
Publicado: (2019)

Treatment with hyperimmune equine immunoglobulin or immunoglobulin fragments completely protects rodents from Ebola virus infection
por: Zheng, Xuexing, et al.
Publicado: (2016)

Influence of Cocktails of Labeled Monoclonal Antibodies on the Localization of Antibodies in Human Tumor Xenografts
por: Watanabe, Yuji, et al.
Publicado: (1990)

Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine
por: Rahim, Md Niaz, et al.
Publicado: (2019)

In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections
por: Andrews, Chasity D., et al.
Publicado: (2017)

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication
por: Rong, Yinghui, et al.
Publicado: (2020)

Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics
por: Liu, Dingjiang, et al.
Publicado: (2021)

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model
por: Patel, Ami, et al.
Publicado: (2018)

Role of the Ebola membrane in the protection conferred by the three-mAb cocktail MIL77
por: Cao, Ping, et al.
Publicado: (2018)

Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus
por: Sivapalasingam, Sumathi, et al.
Publicado: (2021)

Structure of the Inmazeb cocktail and resistance to Ebola virus escape
por: Rayaprolu, Vamseedhar, et al.
Publicado: (2023)

Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails
por: Yuan, Tom Z, et al.
Publicado: (2020)

Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection
por: Tshiani Mbaya, Olivier, et al.
Publicado: (2021)

Antibiotic Combined with Epitope-Specific Monoclonal Antibody Cocktail Protects Mice Against Bacteremia and Acute Pneumonia from Methicillin-Resistant Staphylococcus aureus Infection
por: Duan, LianLi, et al.
Publicado: (2021)

Protective Efficacy of Neutralizing Monoclonal Antibodies in a Nonhuman Primate Model of Ebola Hemorrhagic Fever
por: Marzi, Andrea, et al.
Publicado: (2012)

Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail
por: Froude, Jeffrey W., et al.
Publicado: (2018)

Development of a Mouse Monoclonal Antibody Cocktail for Post-exposure Rabies Prophylaxis in Humans
por: Müller, Thomas, et al.
Publicado: (2009)

A broad-spectrum and highly potent human monoclonal antibody cocktail for rabies prophylaxis
por: Kim, Pan Kyeom, et al.
Publicado: (2021)

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop
por: Banadyga, Logan, et al.
Publicado: (2021)

A novel plant‐made monoclonal antibody enhances the synergetic potency of an antibody cocktail against the SARS‐CoV‐2 Omicron variant
por: Jugler, Collin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2j9cd26p1ir58mq576472aqptf