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Sleep apnea is not associated with worse outcomes in kidney transplant recipients
Obstructive sleep apnea(OSA) is one of the most common sleep disorders in kidney transplant recipients, however its long-term consequences have only rarely been investigated. Here, we hypothesized that the presence of OSA would be associated with higher risk of mortality and faster decline of graft...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381499/ https://www.ncbi.nlm.nih.gov/pubmed/25384581 http://dx.doi.org/10.1038/srep06987 |
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author | Fornadi, Katalin Ronai, Katalin Zsuzsanna Turanyi, Csilla Zita Malavade, Tushar S. Shapiro, Colin Michael Novak, Marta Mucsi, Istvan Molnar, Miklos Z. |
author_facet | Fornadi, Katalin Ronai, Katalin Zsuzsanna Turanyi, Csilla Zita Malavade, Tushar S. Shapiro, Colin Michael Novak, Marta Mucsi, Istvan Molnar, Miklos Z. |
author_sort | Fornadi, Katalin |
collection | PubMed |
description | Obstructive sleep apnea(OSA) is one of the most common sleep disorders in kidney transplant recipients, however its long-term consequences have only rarely been investigated. Here, we hypothesized that the presence of OSA would be associated with higher risk of mortality and faster decline of graft function in kidney transplant recipients. In a prospective cohort study 100 prevalent kidney transplant recipients who underwent one-night polysomnography at baseline and were followed for a median 75 months. Generalized linear mixed-effects models and Cox regression models were used to assess the association between OSA and the rate of progression of chronic kidney disease(CKD) and mortality. The estimated slopes of estimated glomerular filtration rate(eGFR) in patients with and without OSA were compared using a two-stage model of eGFR change including only OSA as a variable. In this model patients with OSA (eGFR versus time was −0.93 ml/min/1.73 m(2)/yr(95%CI:−1.75 to−0.11) had a similar slope as compared to patients without OSA(eGFR versus time was −1.24 ml/min/1.73 m(2)/yr(95%CI: −1.67 to −0.81). In unadjusted Cox proportional regression analyses OSA was not associated with higher all-cause mortality risk (Hazard Ratio(HR) = 1.20; 95% Confidence Interval(CI): 0.50–2.85). No association was found between the presence of OSA and the rate of progression of CKD or all-cause mortality in prevalent kidney transplant recipients. |
format | Online Article Text |
id | pubmed-5381499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53814992017-04-11 Sleep apnea is not associated with worse outcomes in kidney transplant recipients Fornadi, Katalin Ronai, Katalin Zsuzsanna Turanyi, Csilla Zita Malavade, Tushar S. Shapiro, Colin Michael Novak, Marta Mucsi, Istvan Molnar, Miklos Z. Sci Rep Article Obstructive sleep apnea(OSA) is one of the most common sleep disorders in kidney transplant recipients, however its long-term consequences have only rarely been investigated. Here, we hypothesized that the presence of OSA would be associated with higher risk of mortality and faster decline of graft function in kidney transplant recipients. In a prospective cohort study 100 prevalent kidney transplant recipients who underwent one-night polysomnography at baseline and were followed for a median 75 months. Generalized linear mixed-effects models and Cox regression models were used to assess the association between OSA and the rate of progression of chronic kidney disease(CKD) and mortality. The estimated slopes of estimated glomerular filtration rate(eGFR) in patients with and without OSA were compared using a two-stage model of eGFR change including only OSA as a variable. In this model patients with OSA (eGFR versus time was −0.93 ml/min/1.73 m(2)/yr(95%CI:−1.75 to−0.11) had a similar slope as compared to patients without OSA(eGFR versus time was −1.24 ml/min/1.73 m(2)/yr(95%CI: −1.67 to −0.81). In unadjusted Cox proportional regression analyses OSA was not associated with higher all-cause mortality risk (Hazard Ratio(HR) = 1.20; 95% Confidence Interval(CI): 0.50–2.85). No association was found between the presence of OSA and the rate of progression of CKD or all-cause mortality in prevalent kidney transplant recipients. Nature Publishing Group 2014-11-11 /pmc/articles/PMC5381499/ /pubmed/25384581 http://dx.doi.org/10.1038/srep06987 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Fornadi, Katalin Ronai, Katalin Zsuzsanna Turanyi, Csilla Zita Malavade, Tushar S. Shapiro, Colin Michael Novak, Marta Mucsi, Istvan Molnar, Miklos Z. Sleep apnea is not associated with worse outcomes in kidney transplant recipients |
title | Sleep apnea is not associated with worse outcomes in kidney transplant recipients |
title_full | Sleep apnea is not associated with worse outcomes in kidney transplant recipients |
title_fullStr | Sleep apnea is not associated with worse outcomes in kidney transplant recipients |
title_full_unstemmed | Sleep apnea is not associated with worse outcomes in kidney transplant recipients |
title_short | Sleep apnea is not associated with worse outcomes in kidney transplant recipients |
title_sort | sleep apnea is not associated with worse outcomes in kidney transplant recipients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381499/ https://www.ncbi.nlm.nih.gov/pubmed/25384581 http://dx.doi.org/10.1038/srep06987 |
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