Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy

AIMS: The benefit of the β(1)-adrenergic receptor (β(1)-AR) agonist dobutamine for treatment of acute heart failure in peripartum cardiomyopathy (PPCM) is controversial. Cardiac STAT3 expression is reduced in PPCM patients. Mice carrying a cardiomyocyte-restricted deletion of STAT3 (CKO) develop PPC...

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Detalles Bibliográficos
Autores principales: Stapel, Britta, Kohlhaas, Michael, Ricke-Hoch, Melanie, Haghikia, Arash, Erschow, Sergej, Knuuti, Juhani, Silvola, Johanna M. U., Roivainen, Anne, Saraste, Antti, Nickel, Alexander G., Saar, Jasmin A., Sieve, Irina, Pietzsch, Stefan, Müller, Mirco, Bogeski, Ivan, Kappl, Reinhard, Jauhiainen, Matti, Thackeray, James T., Scherr, Michaela, Bengel, Frank M., Hagl, Christian, Tudorache, Igor, Bauersachs, Johann, Maack, Christoph, Hilfiker-Kleiner, Denise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381590/
https://www.ncbi.nlm.nih.gov/pubmed/28201733
http://dx.doi.org/10.1093/eurheartj/ehw086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381590/
https://www.ncbi.nlm.nih.gov/pubmed/28201733
http://dx.doi.org/10.1093/eurheartj/ehw086

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