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A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism

In mammals, UDP-glucose pyrophosphorylase (UGP) is the only enzyme capable of activating glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc), a metabolite located at the intersection of virtually all metabolic pathways in the mammalian cell. Despite the essential role of its product, the molecula...

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Detalles Bibliográficos
Autores principales:	Führing, Jana Indra, Cramer, Johannes Thomas, Schneider, Julia, Baruch, Petra, Gerardy-Schahn, Rita, Fedorov, Roman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381698/ https://www.ncbi.nlm.nih.gov/pubmed/25860585 http://dx.doi.org/10.1038/srep09618

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