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GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data
Hi-C is one of the main methods for investigating spatial co-localisation of DNA in the nucleus. However, the raw sequencing data obtained from Hi-C experiments suffer from large biases and spurious contacts, making it difficult to identify true interactions. Existing methods use complex models to a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381888/ https://www.ncbi.nlm.nih.gov/pubmed/28379994 http://dx.doi.org/10.1371/journal.pone.0174744 |