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Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model

BACKGROUND: The incidence of dengue fever (DF) is steadily increasing in Mexico, burdening health systems with consequent morbidities and mortalities. On December 9(th), 2015, Mexico became the first country for which the dengue vaccine was approved for use. In anticipation of a vaccine rollout, ana...

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Autor principal: Shim, Eunha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381893/
https://www.ncbi.nlm.nih.gov/pubmed/28380060
http://dx.doi.org/10.1371/journal.pone.0175020
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author Shim, Eunha
author_facet Shim, Eunha
author_sort Shim, Eunha
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description BACKGROUND: The incidence of dengue fever (DF) is steadily increasing in Mexico, burdening health systems with consequent morbidities and mortalities. On December 9(th), 2015, Mexico became the first country for which the dengue vaccine was approved for use. In anticipation of a vaccine rollout, analysis of the cost-effectiveness of the dengue vaccination program that quantifies the dynamics of disease transmission is essential. METHODS: We developed a dynamic transmission model of dengue in Yucatán, Mexico and its proposed vaccination program to incorporate herd immunity into our analysis of cost-effectiveness analysis. Our model also incorporates important characteristics of dengue epidemiology, such as clinical cross-immunity and susceptibility enhancement upon secondary infection. Using our model, we evaluated the cost-effectiveness and economic impact of an imperfect dengue vaccine in Yucatán, Mexico. CONCLUSIONS: Our study indicates that a dengue vaccination program would prevent 90% of cases of symptomatic DF incidence as well as 90% of dengue hemorrhagic fever (DHF) incidence and dengue-related deaths annually. We conclude that a dengue vaccine program in Yucatán, Mexico would be very cost-effective as long as the vaccination cost per individual is less than $140 and $214 from health care and societal perspectives, respectively. Furthermore, at an exemplary vaccination cost of $250 USD per individual on average, dengue vaccination is likely to be cost-effective 43% and 88% of the time from health care and societal perspectives, respectively.
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spelling pubmed-53818932017-04-19 Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model Shim, Eunha PLoS One Research Article BACKGROUND: The incidence of dengue fever (DF) is steadily increasing in Mexico, burdening health systems with consequent morbidities and mortalities. On December 9(th), 2015, Mexico became the first country for which the dengue vaccine was approved for use. In anticipation of a vaccine rollout, analysis of the cost-effectiveness of the dengue vaccination program that quantifies the dynamics of disease transmission is essential. METHODS: We developed a dynamic transmission model of dengue in Yucatán, Mexico and its proposed vaccination program to incorporate herd immunity into our analysis of cost-effectiveness analysis. Our model also incorporates important characteristics of dengue epidemiology, such as clinical cross-immunity and susceptibility enhancement upon secondary infection. Using our model, we evaluated the cost-effectiveness and economic impact of an imperfect dengue vaccine in Yucatán, Mexico. CONCLUSIONS: Our study indicates that a dengue vaccination program would prevent 90% of cases of symptomatic DF incidence as well as 90% of dengue hemorrhagic fever (DHF) incidence and dengue-related deaths annually. We conclude that a dengue vaccine program in Yucatán, Mexico would be very cost-effective as long as the vaccination cost per individual is less than $140 and $214 from health care and societal perspectives, respectively. Furthermore, at an exemplary vaccination cost of $250 USD per individual on average, dengue vaccination is likely to be cost-effective 43% and 88% of the time from health care and societal perspectives, respectively. Public Library of Science 2017-04-05 /pmc/articles/PMC5381893/ /pubmed/28380060 http://dx.doi.org/10.1371/journal.pone.0175020 Text en © 2017 Eunha Shim http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shim, Eunha
Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model
title Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model
title_full Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model
title_fullStr Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model
title_full_unstemmed Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model
title_short Cost-effectiveness of dengue vaccination in Yucatán, Mexico using a dynamic dengue transmission model
title_sort cost-effectiveness of dengue vaccination in yucatán, mexico using a dynamic dengue transmission model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381893/
https://www.ncbi.nlm.nih.gov/pubmed/28380060
http://dx.doi.org/10.1371/journal.pone.0175020
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