An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes

APE1 is a multifunctional protein with a DNA base excision repair function in its C-terminal domain and a redox activity in its N-terminal domain. The redox function of APE1 converts certain transcription factors from inactive oxidized to active reduced forms. Given that among the APE1-regulated tra...

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Detalles Bibliográficos
Autores principales: Zhong, Canrong, Xu, Mengyang, Wang, Yan, Xu, Jun, Yuan, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381946/
https://www.ncbi.nlm.nih.gov/pubmed/28380040
http://dx.doi.org/10.1371/journal.ppat.1006289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381946/
https://www.ncbi.nlm.nih.gov/pubmed/28380040
http://dx.doi.org/10.1371/journal.ppat.1006289

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