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Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

BACKGROUND: The objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT),...

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Autores principales: Ríos-Toro, Juan-Jesús, Márquez-Coello, Mercedes, García-Álvarez, José-María, Martín-Aspas, Andrés, Rivera-Fernández, Ricardo, Sáez de Benito, Ana, Girón-González, José-Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381948/
https://www.ncbi.nlm.nih.gov/pubmed/28380034
http://dx.doi.org/10.1371/journal.pone.0175254
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author Ríos-Toro, Juan-Jesús
Márquez-Coello, Mercedes
García-Álvarez, José-María
Martín-Aspas, Andrés
Rivera-Fernández, Ricardo
Sáez de Benito, Ana
Girón-González, José-Antonio
author_facet Ríos-Toro, Juan-Jesús
Márquez-Coello, Mercedes
García-Álvarez, José-María
Martín-Aspas, Andrés
Rivera-Fernández, Ricardo
Sáez de Benito, Ana
Girón-González, José-Antonio
author_sort Ríos-Toro, Juan-Jesús
collection PubMed
description BACKGROUND: The objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for patients with severe sepsis and septic shock in an intensive care unit (ICU). METHODS: Fifty patients admitted at the ICU with the diagnosis of severe sepsis or septic shock were studied. SOFA and APACHE II scores as well as serum biomarkers were measured at days 0, 2 and 5. The influence of these variables on 28-day mortality was analyzed. Twenty healthy individuals served as controls. RESULTS: Baseline serum concentrations of sTREM-1, sCD163, IL-6 and PCT correlated with SOFA score. Only sTREM-1 levels correlated with APACHE II score. The 28-day mortality rate for all patients was 42%. The absence of risk factors for infection, presence of septic shock, baseline values of sCD14 and decrease of PCT and IL-6 from baseline to day 5 were variables associated to mortality in the univariate analysis. The unique independent factor associated to mortality in the multivariate analysis was a decrease of PCT higher than 50% from days 0 to 5. CONCLUSIONS: Serum levels of sTREM-1 are correlated with the severity of sepsis. A 50% decrease of PCT was the unique variable associated with survival in the multivariate analysis.
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spelling pubmed-53819482017-04-19 Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock Ríos-Toro, Juan-Jesús Márquez-Coello, Mercedes García-Álvarez, José-María Martín-Aspas, Andrés Rivera-Fernández, Ricardo Sáez de Benito, Ana Girón-González, José-Antonio PLoS One Research Article BACKGROUND: The objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for patients with severe sepsis and septic shock in an intensive care unit (ICU). METHODS: Fifty patients admitted at the ICU with the diagnosis of severe sepsis or septic shock were studied. SOFA and APACHE II scores as well as serum biomarkers were measured at days 0, 2 and 5. The influence of these variables on 28-day mortality was analyzed. Twenty healthy individuals served as controls. RESULTS: Baseline serum concentrations of sTREM-1, sCD163, IL-6 and PCT correlated with SOFA score. Only sTREM-1 levels correlated with APACHE II score. The 28-day mortality rate for all patients was 42%. The absence of risk factors for infection, presence of septic shock, baseline values of sCD14 and decrease of PCT and IL-6 from baseline to day 5 were variables associated to mortality in the univariate analysis. The unique independent factor associated to mortality in the multivariate analysis was a decrease of PCT higher than 50% from days 0 to 5. CONCLUSIONS: Serum levels of sTREM-1 are correlated with the severity of sepsis. A 50% decrease of PCT was the unique variable associated with survival in the multivariate analysis. Public Library of Science 2017-04-05 /pmc/articles/PMC5381948/ /pubmed/28380034 http://dx.doi.org/10.1371/journal.pone.0175254 Text en © 2017 Ríos-Toro et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ríos-Toro, Juan-Jesús
Márquez-Coello, Mercedes
García-Álvarez, José-María
Martín-Aspas, Andrés
Rivera-Fernández, Ricardo
Sáez de Benito, Ana
Girón-González, José-Antonio
Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock
title Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock
title_full Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock
title_fullStr Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock
title_full_unstemmed Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock
title_short Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock
title_sort soluble membrane receptors, interleukin 6, procalcitonin and c reactive protein as prognostic markers in patients with severe sepsis and septic shock
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381948/
https://www.ncbi.nlm.nih.gov/pubmed/28380034
http://dx.doi.org/10.1371/journal.pone.0175254
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