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Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis
BACKGROUND: Studies on the effect of air pollutions on kidney diseases are still limited. OBJECTIVE: We aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. METHODS: We recruited 21,656 adults as participants from 2007 to 2009. The Taiwanes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381984/ https://www.ncbi.nlm.nih.gov/pubmed/27713105 http://dx.doi.org/10.1289/EHP302 |
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author | Yang, Ya-Ru Chen, Yung-Ming Chen, Szu-Ying Chan, Chang-Chuan |
author_facet | Yang, Ya-Ru Chen, Yung-Ming Chen, Szu-Ying Chan, Chang-Chuan |
author_sort | Yang, Ya-Ru |
collection | PubMed |
description | BACKGROUND: Studies on the effect of air pollutions on kidney diseases are still limited. OBJECTIVE: We aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. METHODS: We recruited 21,656 adults as participants from 2007 to 2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m(2) were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter < 10 μm (PM(10)), coarse particles (PM(Coarse)), fine particles (PM(2.5)), and PM(2.5Absorbance). Generalized linear and logistic regression models were used to estimate the associations between PM exposure and renal function. RESULTS: An IQR increase in PM(10) (5.83 μg/m(3)) was negatively associated with eGFR by –0.69 (95% CI: –0.89, –0.48) mL/min/1.73 m(2) and positively associated with the prevalence of CKD with adjusted OR = 1.15 (95% CI: 1.07, 1.23). An IQR increase in PM(Coarse) (6.59 μg/m(3)) was significantly associated with lower eGFR by –1.07 (95% CI: –1.32, –0.81) mL/min/1.73 m(2) and CKD with OR = 1.26 (95% CI: 1.15, 1.38). In contrast, neither outcome was significantly associated with PM(2.5) or PM(2.5Absorbance). Stratified analyses indicated that associations of CKD with both PM(10) and PM(Coarse) were limited to participants < 65 years of age, and were stronger (for PM(10)) or limited to (PM(Coarse)) women. Associations also appeared to be stronger in those without (vs. with) hypertension, and in normal versus overweight participants. CONCLUSIONS: Exposure during the previous year to PM(10) and PM(Coarse), but not PM(2.5) or PM(2.5Absorbance), was associated with reduced renal function among Taiwanese adults. CITATION: Yang YR, Chen YM, Chen SY, Chan CC. 2017. Associations between long-term particulate matter exposure and adult renal function in the Taipei metropolis. Environ Health Perspect 125:602–607; http://dx.doi.org/10.1289/EHP302 |
format | Online Article Text |
id | pubmed-5381984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-53819842017-04-15 Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis Yang, Ya-Ru Chen, Yung-Ming Chen, Szu-Ying Chan, Chang-Chuan Environ Health Perspect Research BACKGROUND: Studies on the effect of air pollutions on kidney diseases are still limited. OBJECTIVE: We aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults. METHODS: We recruited 21,656 adults as participants from 2007 to 2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m(2) were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter < 10 μm (PM(10)), coarse particles (PM(Coarse)), fine particles (PM(2.5)), and PM(2.5Absorbance). Generalized linear and logistic regression models were used to estimate the associations between PM exposure and renal function. RESULTS: An IQR increase in PM(10) (5.83 μg/m(3)) was negatively associated with eGFR by –0.69 (95% CI: –0.89, –0.48) mL/min/1.73 m(2) and positively associated with the prevalence of CKD with adjusted OR = 1.15 (95% CI: 1.07, 1.23). An IQR increase in PM(Coarse) (6.59 μg/m(3)) was significantly associated with lower eGFR by –1.07 (95% CI: –1.32, –0.81) mL/min/1.73 m(2) and CKD with OR = 1.26 (95% CI: 1.15, 1.38). In contrast, neither outcome was significantly associated with PM(2.5) or PM(2.5Absorbance). Stratified analyses indicated that associations of CKD with both PM(10) and PM(Coarse) were limited to participants < 65 years of age, and were stronger (for PM(10)) or limited to (PM(Coarse)) women. Associations also appeared to be stronger in those without (vs. with) hypertension, and in normal versus overweight participants. CONCLUSIONS: Exposure during the previous year to PM(10) and PM(Coarse), but not PM(2.5) or PM(2.5Absorbance), was associated with reduced renal function among Taiwanese adults. CITATION: Yang YR, Chen YM, Chen SY, Chan CC. 2017. Associations between long-term particulate matter exposure and adult renal function in the Taipei metropolis. Environ Health Perspect 125:602–607; http://dx.doi.org/10.1289/EHP302 National Institute of Environmental Health Sciences 2016-10-07 2017-04 /pmc/articles/PMC5381984/ /pubmed/27713105 http://dx.doi.org/10.1289/EHP302 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Yang, Ya-Ru Chen, Yung-Ming Chen, Szu-Ying Chan, Chang-Chuan Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis |
title | Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis |
title_full | Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis |
title_fullStr | Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis |
title_full_unstemmed | Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis |
title_short | Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis |
title_sort | associations between long-term particulate matter exposure and adult renal function in the taipei metropolis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381984/ https://www.ncbi.nlm.nih.gov/pubmed/27713105 http://dx.doi.org/10.1289/EHP302 |
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