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Biomonitoring in the Era of the Exposome
BACKGROUND: The term “exposome” was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts. OBJE...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381997/ https://www.ncbi.nlm.nih.gov/pubmed/27385067 http://dx.doi.org/10.1289/EHP474 |
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author | Dennis, Kristine K. Marder, Elizabeth Balshaw, David M. Cui, Yuxia Lynes, Michael A. Patti, Gary J. Rappaport, Stephen M. Shaughnessy, Daniel T. Vrijheid, Martine Barr, Dana Boyd |
author_facet | Dennis, Kristine K. Marder, Elizabeth Balshaw, David M. Cui, Yuxia Lynes, Michael A. Patti, Gary J. Rappaport, Stephen M. Shaughnessy, Daniel T. Vrijheid, Martine Barr, Dana Boyd |
author_sort | Dennis, Kristine K. |
collection | PubMed |
description | BACKGROUND: The term “exposome” was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts. OBJECTIVES: Our objectives were to describe why traditional and nontraditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and to make recommendations on how to transition exposure research toward exposomic approaches. We describe the biomonitoring needs of exposome research and approaches and recommendations that will help fill the gaps in the current science. DISCUSSION: Traditional and exposomic biomonitoring approaches have key advantages and disadvantages for assessing exposure. Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources. Issues of sample availability and quality, identification of unknown analytes, capture of nonpersistent chemicals, integration of methods, and statistical assessment of increasingly complex data sets remain challenges that must continue to be addressed. CONCLUSIONS: To understand the complexity of exposures faced throughout the lifespan, both traditional and nontraditional biomonitoring methods should be used. Through hybrid approaches and the integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome. CITATION: Dennis KK, Marder E, Balshaw DM, Cui Y, Lynes MA, Patti GJ, Rappaport SM, Shaughnessy DT, Vrijheid M, Barr DB. 2017. Biomonitoring in the era of the exposome. Environ Health Perspect 125:502–510; http://dx.doi.org/10.1289/EHP474 |
format | Online Article Text |
id | pubmed-5381997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-53819972017-04-15 Biomonitoring in the Era of the Exposome Dennis, Kristine K. Marder, Elizabeth Balshaw, David M. Cui, Yuxia Lynes, Michael A. Patti, Gary J. Rappaport, Stephen M. Shaughnessy, Daniel T. Vrijheid, Martine Barr, Dana Boyd Environ Health Perspect Commentary BACKGROUND: The term “exposome” was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts. OBJECTIVES: Our objectives were to describe why traditional and nontraditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and to make recommendations on how to transition exposure research toward exposomic approaches. We describe the biomonitoring needs of exposome research and approaches and recommendations that will help fill the gaps in the current science. DISCUSSION: Traditional and exposomic biomonitoring approaches have key advantages and disadvantages for assessing exposure. Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources. Issues of sample availability and quality, identification of unknown analytes, capture of nonpersistent chemicals, integration of methods, and statistical assessment of increasingly complex data sets remain challenges that must continue to be addressed. CONCLUSIONS: To understand the complexity of exposures faced throughout the lifespan, both traditional and nontraditional biomonitoring methods should be used. Through hybrid approaches and the integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome. CITATION: Dennis KK, Marder E, Balshaw DM, Cui Y, Lynes MA, Patti GJ, Rappaport SM, Shaughnessy DT, Vrijheid M, Barr DB. 2017. Biomonitoring in the era of the exposome. Environ Health Perspect 125:502–510; http://dx.doi.org/10.1289/EHP474 National Institute of Environmental Health Sciences 2016-07-06 2017-04 /pmc/articles/PMC5381997/ /pubmed/27385067 http://dx.doi.org/10.1289/EHP474 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Commentary Dennis, Kristine K. Marder, Elizabeth Balshaw, David M. Cui, Yuxia Lynes, Michael A. Patti, Gary J. Rappaport, Stephen M. Shaughnessy, Daniel T. Vrijheid, Martine Barr, Dana Boyd Biomonitoring in the Era of the Exposome |
title | Biomonitoring in the Era of the Exposome |
title_full | Biomonitoring in the Era of the Exposome |
title_fullStr | Biomonitoring in the Era of the Exposome |
title_full_unstemmed | Biomonitoring in the Era of the Exposome |
title_short | Biomonitoring in the Era of the Exposome |
title_sort | biomonitoring in the era of the exposome |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381997/ https://www.ncbi.nlm.nih.gov/pubmed/27385067 http://dx.doi.org/10.1289/EHP474 |
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