Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole

Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose pos...

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Autores principales: Bunskoek, Paulien E., Seyedmousavi, Seyedmojtaba, Gans, Steven J.M., van Vierzen, Peter B.J., Melchers, Willem J.G., van Elk, Cornelis E., Mouton, Johan W., Verweij, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382031/
https://www.ncbi.nlm.nih.gov/pubmed/28409094
http://dx.doi.org/10.1016/j.mmcr.2017.03.005
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author Bunskoek, Paulien E.
Seyedmousavi, Seyedmojtaba
Gans, Steven J.M.
van Vierzen, Peter B.J.
Melchers, Willem J.G.
van Elk, Cornelis E.
Mouton, Johan W.
Verweij, Paul E.
author_facet Bunskoek, Paulien E.
Seyedmousavi, Seyedmojtaba
Gans, Steven J.M.
van Vierzen, Peter B.J.
Melchers, Willem J.G.
van Elk, Cornelis E.
Mouton, Johan W.
Verweij, Paul E.
author_sort Bunskoek, Paulien E.
collection PubMed
description Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose posaconazole was initiated aimed at achieving trough levels exceeding 3 mg/l. Posaconazole serum levels of 3–9.5 mg/l were achieved without significant side-effects. Follow-up bronchoscopy and computed tomography showed complete resolution of the lesions.
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spelling pubmed-53820312017-04-13 Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole Bunskoek, Paulien E. Seyedmousavi, Seyedmojtaba Gans, Steven J.M. van Vierzen, Peter B.J. Melchers, Willem J.G. van Elk, Cornelis E. Mouton, Johan W. Verweij, Paul E. Med Mycol Case Rep Case Report Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose posaconazole was initiated aimed at achieving trough levels exceeding 3 mg/l. Posaconazole serum levels of 3–9.5 mg/l were achieved without significant side-effects. Follow-up bronchoscopy and computed tomography showed complete resolution of the lesions. Elsevier 2017-04-01 /pmc/articles/PMC5382031/ /pubmed/28409094 http://dx.doi.org/10.1016/j.mmcr.2017.03.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Bunskoek, Paulien E.
Seyedmousavi, Seyedmojtaba
Gans, Steven J.M.
van Vierzen, Peter B.J.
Melchers, Willem J.G.
van Elk, Cornelis E.
Mouton, Johan W.
Verweij, Paul E.
Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
title Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
title_full Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
title_fullStr Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
title_full_unstemmed Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
title_short Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
title_sort successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382031/
https://www.ncbi.nlm.nih.gov/pubmed/28409094
http://dx.doi.org/10.1016/j.mmcr.2017.03.005
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