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Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis
Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. Th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382045/ https://www.ncbi.nlm.nih.gov/pubmed/28378540 http://dx.doi.org/10.3947/ic.2017.49.1.10 |
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author | Park, Dae Won Zmijewski, Jaroslaw W |
author_facet | Park, Dae Won Zmijewski, Jaroslaw W |
author_sort | Park, Dae Won |
collection | PubMed |
description | Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities. |
format | Online Article Text |
id | pubmed-5382045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Society of Infectious Diseases and Korean Society for Chemotherapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-53820452017-04-06 Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis Park, Dae Won Zmijewski, Jaroslaw W Infect Chemother Review Article Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2017-03 2017-03-23 /pmc/articles/PMC5382045/ /pubmed/28378540 http://dx.doi.org/10.3947/ic.2017.49.1.10 Text en Copyright © 2017 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Park, Dae Won Zmijewski, Jaroslaw W Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis |
title | Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis |
title_full | Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis |
title_fullStr | Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis |
title_full_unstemmed | Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis |
title_short | Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis |
title_sort | mitochondrial dysfunction and immune cell metabolism in sepsis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382045/ https://www.ncbi.nlm.nih.gov/pubmed/28378540 http://dx.doi.org/10.3947/ic.2017.49.1.10 |
work_keys_str_mv | AT parkdaewon mitochondrialdysfunctionandimmunecellmetabolisminsepsis AT zmijewskijaroslaww mitochondrialdysfunctionandimmunecellmetabolisminsepsis |