Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria

Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria use...

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Detalles Bibliográficos
Autores principales: Park, Jung Yeon, Park, Chulmin, Chun, Hye-Sun, Byun, Ji-Hyun, Cho, Sung-Yeon, Lee, Dong-Gun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382051/
https://www.ncbi.nlm.nih.gov/pubmed/28271653
http://dx.doi.org/10.3947/ic.2017.49.1.57
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author Park, Jung Yeon
Park, Chulmin
Chun, Hye-Sun
Byun, Ji-Hyun
Cho, Sung-Yeon
Lee, Dong-Gun
author_facet Park, Jung Yeon
Park, Chulmin
Chun, Hye-Sun
Byun, Ji-Hyun
Cho, Sung-Yeon
Lee, Dong-Gun
author_sort Park, Jung Yeon
collection PubMed
description Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea.
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spelling pubmed-53820512017-04-06 Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria Park, Jung Yeon Park, Chulmin Chun, Hye-Sun Byun, Ji-Hyun Cho, Sung-Yeon Lee, Dong-Gun Infect Chemother Brief Communication Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2017-03 2017-03-06 /pmc/articles/PMC5382051/ /pubmed/28271653 http://dx.doi.org/10.3947/ic.2017.49.1.57 Text en Copyright © 2017 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Park, Jung Yeon
Park, Chulmin
Chun, Hye-Sun
Byun, Ji-Hyun
Cho, Sung-Yeon
Lee, Dong-Gun
Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
title Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
title_full Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
title_fullStr Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
title_full_unstemmed Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
title_short Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
title_sort establishment of experimental murine peritonitis model with hog gastric mucin for carbapenem-resistant gram-negative bacteria
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382051/
https://www.ncbi.nlm.nih.gov/pubmed/28271653
http://dx.doi.org/10.3947/ic.2017.49.1.57
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