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Combination of IL-10 and IL-2 induces oligoclonal human CD4 T cell expansion during xenogeneic and allogeneic GVHD in humanized mice

IL-10 is a crucial anti-inflammatory cytokine which can also exert a seemingly divergent immunostimulatory effects under certain conditions. We found high levels of the cytokine in a xenogeneic GVHD model where NOD-scid IL2rγcnull (NSG) mice were transplanted with human PBMCs in presence of IL-2. Pr...

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Detalles Bibliográficos
Autores principales:	Abraham, Sojan, Guo, Hua, Choi, Jang-gi, Ye, Chunting, Thomas, Midhun Ben, Ortega, Nora, Dwivedi, Alok, Manjunath, N., Yi, Guohua, Shankar, Premlata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382148/ https://www.ncbi.nlm.nih.gov/pubmed/28409183 http://dx.doi.org/10.1016/j.heliyon.2017.e00276

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