Cargando…
Tetraspanins Function as Regulators of Cellular Signaling
Tetraspanins are molecular scaffolds that distribute proteins into highly organized microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have identified interactions between tetraspanins and signaling molecules, finding unique downstream cellular consequences. In this r...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382171/ https://www.ncbi.nlm.nih.gov/pubmed/28428953 http://dx.doi.org/10.3389/fcell.2017.00034 |
_version_ | 1782520049693622272 |
---|---|
author | Termini, Christina M. Gillette, Jennifer M. |
author_facet | Termini, Christina M. Gillette, Jennifer M. |
author_sort | Termini, Christina M. |
collection | PubMed |
description | Tetraspanins are molecular scaffolds that distribute proteins into highly organized microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have identified interactions between tetraspanins and signaling molecules, finding unique downstream cellular consequences. In this review, we will explore these interactions as well as the specific cellular responses to signal activation, focusing on tetraspanin regulation of adhesion-mediated (integrins/FAK), receptor-mediated (EGFR, TNF-α, c-Met, c-Kit), and intracellular signaling (PKC, PI4K, β-catenin). Additionally, we will summarize our current understanding for how tetraspanin post-translational modifications (palmitoylation, N-linked glycosylation, and ubiquitination) can regulate signal propagation. Many of the studies outlined in this review suggest that tetraspanins offer a potential therapeutic target to modulate aberrant signal transduction pathways that directly impact a host of cellular behaviors and disease states. |
format | Online Article Text |
id | pubmed-5382171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53821712017-04-20 Tetraspanins Function as Regulators of Cellular Signaling Termini, Christina M. Gillette, Jennifer M. Front Cell Dev Biol Cell and Developmental Biology Tetraspanins are molecular scaffolds that distribute proteins into highly organized microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have identified interactions between tetraspanins and signaling molecules, finding unique downstream cellular consequences. In this review, we will explore these interactions as well as the specific cellular responses to signal activation, focusing on tetraspanin regulation of adhesion-mediated (integrins/FAK), receptor-mediated (EGFR, TNF-α, c-Met, c-Kit), and intracellular signaling (PKC, PI4K, β-catenin). Additionally, we will summarize our current understanding for how tetraspanin post-translational modifications (palmitoylation, N-linked glycosylation, and ubiquitination) can regulate signal propagation. Many of the studies outlined in this review suggest that tetraspanins offer a potential therapeutic target to modulate aberrant signal transduction pathways that directly impact a host of cellular behaviors and disease states. Frontiers Media S.A. 2017-04-06 /pmc/articles/PMC5382171/ /pubmed/28428953 http://dx.doi.org/10.3389/fcell.2017.00034 Text en Copyright © 2017 Termini and Gillette. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Termini, Christina M. Gillette, Jennifer M. Tetraspanins Function as Regulators of Cellular Signaling |
title | Tetraspanins Function as Regulators of Cellular Signaling |
title_full | Tetraspanins Function as Regulators of Cellular Signaling |
title_fullStr | Tetraspanins Function as Regulators of Cellular Signaling |
title_full_unstemmed | Tetraspanins Function as Regulators of Cellular Signaling |
title_short | Tetraspanins Function as Regulators of Cellular Signaling |
title_sort | tetraspanins function as regulators of cellular signaling |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382171/ https://www.ncbi.nlm.nih.gov/pubmed/28428953 http://dx.doi.org/10.3389/fcell.2017.00034 |
work_keys_str_mv | AT terminichristinam tetraspaninsfunctionasregulatorsofcellularsignaling AT gillettejenniferm tetraspaninsfunctionasregulatorsofcellularsignaling |