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Uncovering the Roles of Septins in Cilia
Septins are a family of GTP-binding proteins that associate with cellular membranes and the cytoskeleton. Their ability to polymerize into filamentous structures permits them to serve as diffusion barriers for membrane proteins and as multi-molecular scaffolds that recruit components of signaling pa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382219/ https://www.ncbi.nlm.nih.gov/pubmed/28428954 http://dx.doi.org/10.3389/fcell.2017.00036 |
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author | Palander, Oliva El-Zeiry, Maha Trimble, William S. |
author_facet | Palander, Oliva El-Zeiry, Maha Trimble, William S. |
author_sort | Palander, Oliva |
collection | PubMed |
description | Septins are a family of GTP-binding proteins that associate with cellular membranes and the cytoskeleton. Their ability to polymerize into filamentous structures permits them to serve as diffusion barriers for membrane proteins and as multi-molecular scaffolds that recruit components of signaling pathways. At the cellular level, septins contribute to the regulation of numerous processes, including cytokinesis, cell polarity, cell migration, and many others. In this review, we discuss emerging evidence for roles of mammalian septins in the biogenesis and function of flagella and cilia, and how this may impact human diseases such as ciliopathies. |
format | Online Article Text |
id | pubmed-5382219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53822192017-04-20 Uncovering the Roles of Septins in Cilia Palander, Oliva El-Zeiry, Maha Trimble, William S. Front Cell Dev Biol Cell and Developmental Biology Septins are a family of GTP-binding proteins that associate with cellular membranes and the cytoskeleton. Their ability to polymerize into filamentous structures permits them to serve as diffusion barriers for membrane proteins and as multi-molecular scaffolds that recruit components of signaling pathways. At the cellular level, septins contribute to the regulation of numerous processes, including cytokinesis, cell polarity, cell migration, and many others. In this review, we discuss emerging evidence for roles of mammalian septins in the biogenesis and function of flagella and cilia, and how this may impact human diseases such as ciliopathies. Frontiers Media S.A. 2017-04-06 /pmc/articles/PMC5382219/ /pubmed/28428954 http://dx.doi.org/10.3389/fcell.2017.00036 Text en Copyright © 2017 Palander, El-Zeiry and Trimble. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Palander, Oliva El-Zeiry, Maha Trimble, William S. Uncovering the Roles of Septins in Cilia |
title | Uncovering the Roles of Septins in Cilia |
title_full | Uncovering the Roles of Septins in Cilia |
title_fullStr | Uncovering the Roles of Septins in Cilia |
title_full_unstemmed | Uncovering the Roles of Septins in Cilia |
title_short | Uncovering the Roles of Septins in Cilia |
title_sort | uncovering the roles of septins in cilia |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382219/ https://www.ncbi.nlm.nih.gov/pubmed/28428954 http://dx.doi.org/10.3389/fcell.2017.00036 |
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