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Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication
Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the Cdc48 “segregase”. Here, we employ a screen to identify partners...
Autores principales: | Maric, Marija, Mukherjee, Progya, Tatham, Michael H., Hay, Ronald, Labib, Karim |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382235/ https://www.ncbi.nlm.nih.gov/pubmed/28355556 http://dx.doi.org/10.1016/j.celrep.2017.03.020 |
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