Altered Synapse Stability in the Early Stages of Tauopathy

Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopa...

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Detalles Bibliográficos
Autores principales: Jackson, Johanna S., Witton, Jonathan, Johnson, James D., Ahmed, Zeshan, Ward, Mark, Randall, Andrew D., Hutton, Michael L., Isaac, John T., O’Neill, Michael J., Ashby, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382238/
https://www.ncbi.nlm.nih.gov/pubmed/28355559
http://dx.doi.org/10.1016/j.celrep.2017.03.013

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