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Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines

The Pictet–Spengler reaction (PSR) involves the condensation and ring closure between a β-arylethylamine and a carbonyl compound. The combination of dopamine and ketones in a PSR leads to the formation of 1,1′-disubstituted tetrahydroisoquinolines (THIQs), structures that are challenging to synthesi...

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Detalles Bibliográficos
Autores principales:	Lichman, Benjamin R., Zhao, Jianxiong, Hailes, Helen C., Ward, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382262/ https://www.ncbi.nlm.nih.gov/pubmed/28368003 http://dx.doi.org/10.1038/ncomms14883

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