A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Conditional expression of diphtheria toxin receptor (DTR) is widely used for tissue-specific ablation of cells. However, diphtheria toxin (DT) crosses the blood–brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are also expressed in the central nervous syst...

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Detalles Bibliográficos
Autores principales: Pereira, Mafalda M. A., Mahú, Inês, Seixas, Elsa, Martinéz-Sánchez, Noelia, Kubasova, Nadiya, Pirzgalska, Roksana M, Cohen, Paul, Dietrich, Marcelo O, López, Miguel, Bernardes, Gonçalo J. L., Domingos, Ana I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382263/
https://www.ncbi.nlm.nih.gov/pubmed/28367972
http://dx.doi.org/10.1038/ncomms14967

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