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Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discuss...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382417/ https://www.ncbi.nlm.nih.gov/pubmed/28381261 http://dx.doi.org/10.1186/s12936-017-1784-1 |
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author | Thriemer, Kamala Ley, Benedikt Bobogare, Albino Dysoley, Lek Alam, Mohammad Shafiul Pasaribu, Ayodhia P. Sattabongkot, Jetsumon Jambert, Elodie Domingo, Gonzalo J. Commons, Robert Auburn, Sarah Marfurt, Jutta Devine, Angela Aktaruzzaman, Mohammad M. Sohel, Nayeem Namgay, Rinzin Drukpa, Tobgyel Sharma, Surender Nath Sarawati, Elvieda Samad, Iriani Theodora, Minerva Nambanya, Simone Ounekham, Sonesay Mudin, Rose Nanti Binti Da Thakur, Garib Makita, Leo Sora Deray, Raffy Lee, Sang-Eun Boaz, Leonard Danansuriya, Manjula N. Mudiyanselage, Santha D. Chinanonwait, Nipon Kitchakarn, Suravadee Nausien, Johnny Naket, Esau Duc, Thang Ngo Do Manh, Ha Hong, Young S. Cheng, Qin Richards, Jack S. Kusriastuti, Rita Satyagraha, Ari Noviyanti, Rintis Ding, Xavier C. Khan, Wasif Ali Swe Phru, Ching Guoding, Zhu Qi, Gao Kaneko, Akira Miotto, Olivo Nguitragool, Wang Roobsoong, Wanlapa Battle, Katherine Howes, Rosalind E. Roca-Feltrer, Arantxa Duparc, Stephan Bhowmick, Ipsita Pal Kenangalem, Enny Bibit, Jo-Anne Barry, Alyssa Sintasath, David Abeyasinghe, Rabindra Sibley, Carol H. McCarthy, James von Seidlein, Lorenz Baird, J. Kevin Price, Ric N. |
author_facet | Thriemer, Kamala Ley, Benedikt Bobogare, Albino Dysoley, Lek Alam, Mohammad Shafiul Pasaribu, Ayodhia P. Sattabongkot, Jetsumon Jambert, Elodie Domingo, Gonzalo J. Commons, Robert Auburn, Sarah Marfurt, Jutta Devine, Angela Aktaruzzaman, Mohammad M. Sohel, Nayeem Namgay, Rinzin Drukpa, Tobgyel Sharma, Surender Nath Sarawati, Elvieda Samad, Iriani Theodora, Minerva Nambanya, Simone Ounekham, Sonesay Mudin, Rose Nanti Binti Da Thakur, Garib Makita, Leo Sora Deray, Raffy Lee, Sang-Eun Boaz, Leonard Danansuriya, Manjula N. Mudiyanselage, Santha D. Chinanonwait, Nipon Kitchakarn, Suravadee Nausien, Johnny Naket, Esau Duc, Thang Ngo Do Manh, Ha Hong, Young S. Cheng, Qin Richards, Jack S. Kusriastuti, Rita Satyagraha, Ari Noviyanti, Rintis Ding, Xavier C. Khan, Wasif Ali Swe Phru, Ching Guoding, Zhu Qi, Gao Kaneko, Akira Miotto, Olivo Nguitragool, Wang Roobsoong, Wanlapa Battle, Katherine Howes, Rosalind E. Roca-Feltrer, Arantxa Duparc, Stephan Bhowmick, Ipsita Pal Kenangalem, Enny Bibit, Jo-Anne Barry, Alyssa Sintasath, David Abeyasinghe, Rabindra Sibley, Carol H. McCarthy, James von Seidlein, Lorenz Baird, J. Kevin Price, Ric N. |
author_sort | Thriemer, Kamala |
collection | PubMed |
description | The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes. In this meeting report, the key discussion points are presented and grouped into five themes: (i) current barriers for glucose-6-phosphate deficiency (G6PD) testing prior to PQ radical cure, (ii) necessary properties of G6PD tests for wide scale deployment, (iii) the promotion of G6PD testing, (iv) improving adherence to PQ regimens and (v) the challenges for future tafenoquine (TQ) roll out. Robust point of care (PoC) G6PD tests are needed, which are suitable and cost-effective for clinical settings with limited infrastructure. An affordable and competitive test price is needed, accompanied by sustainable funding for the product with appropriate training of healthcare staff, and robust quality control and assurance processes. In the absence of quantitative PoC G6PD tests, G6PD status can be gauged with qualitative diagnostics, however none of the available tests is currently sensitive enough to guide TQ treatment. TQ introduction will require overcoming additional challenges including the management of severely and intermediately G6PD deficient individuals. Robust strategies are needed to ensure that effective treatment practices can be deployed widely, and these should ensure that the caveats are outweighed by the benefits of radical cure for both the patients and the community. Widespread access to quality controlled G6PD testing will be critical. |
format | Online Article Text |
id | pubmed-5382417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53824172017-04-10 Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group Thriemer, Kamala Ley, Benedikt Bobogare, Albino Dysoley, Lek Alam, Mohammad Shafiul Pasaribu, Ayodhia P. Sattabongkot, Jetsumon Jambert, Elodie Domingo, Gonzalo J. Commons, Robert Auburn, Sarah Marfurt, Jutta Devine, Angela Aktaruzzaman, Mohammad M. Sohel, Nayeem Namgay, Rinzin Drukpa, Tobgyel Sharma, Surender Nath Sarawati, Elvieda Samad, Iriani Theodora, Minerva Nambanya, Simone Ounekham, Sonesay Mudin, Rose Nanti Binti Da Thakur, Garib Makita, Leo Sora Deray, Raffy Lee, Sang-Eun Boaz, Leonard Danansuriya, Manjula N. Mudiyanselage, Santha D. Chinanonwait, Nipon Kitchakarn, Suravadee Nausien, Johnny Naket, Esau Duc, Thang Ngo Do Manh, Ha Hong, Young S. Cheng, Qin Richards, Jack S. Kusriastuti, Rita Satyagraha, Ari Noviyanti, Rintis Ding, Xavier C. Khan, Wasif Ali Swe Phru, Ching Guoding, Zhu Qi, Gao Kaneko, Akira Miotto, Olivo Nguitragool, Wang Roobsoong, Wanlapa Battle, Katherine Howes, Rosalind E. Roca-Feltrer, Arantxa Duparc, Stephan Bhowmick, Ipsita Pal Kenangalem, Enny Bibit, Jo-Anne Barry, Alyssa Sintasath, David Abeyasinghe, Rabindra Sibley, Carol H. McCarthy, James von Seidlein, Lorenz Baird, J. Kevin Price, Ric N. Malar J Meeting Report The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes. In this meeting report, the key discussion points are presented and grouped into five themes: (i) current barriers for glucose-6-phosphate deficiency (G6PD) testing prior to PQ radical cure, (ii) necessary properties of G6PD tests for wide scale deployment, (iii) the promotion of G6PD testing, (iv) improving adherence to PQ regimens and (v) the challenges for future tafenoquine (TQ) roll out. Robust point of care (PoC) G6PD tests are needed, which are suitable and cost-effective for clinical settings with limited infrastructure. An affordable and competitive test price is needed, accompanied by sustainable funding for the product with appropriate training of healthcare staff, and robust quality control and assurance processes. In the absence of quantitative PoC G6PD tests, G6PD status can be gauged with qualitative diagnostics, however none of the available tests is currently sensitive enough to guide TQ treatment. TQ introduction will require overcoming additional challenges including the management of severely and intermediately G6PD deficient individuals. Robust strategies are needed to ensure that effective treatment practices can be deployed widely, and these should ensure that the caveats are outweighed by the benefits of radical cure for both the patients and the community. Widespread access to quality controlled G6PD testing will be critical. BioMed Central 2017-04-05 /pmc/articles/PMC5382417/ /pubmed/28381261 http://dx.doi.org/10.1186/s12936-017-1784-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Meeting Report Thriemer, Kamala Ley, Benedikt Bobogare, Albino Dysoley, Lek Alam, Mohammad Shafiul Pasaribu, Ayodhia P. Sattabongkot, Jetsumon Jambert, Elodie Domingo, Gonzalo J. Commons, Robert Auburn, Sarah Marfurt, Jutta Devine, Angela Aktaruzzaman, Mohammad M. Sohel, Nayeem Namgay, Rinzin Drukpa, Tobgyel Sharma, Surender Nath Sarawati, Elvieda Samad, Iriani Theodora, Minerva Nambanya, Simone Ounekham, Sonesay Mudin, Rose Nanti Binti Da Thakur, Garib Makita, Leo Sora Deray, Raffy Lee, Sang-Eun Boaz, Leonard Danansuriya, Manjula N. Mudiyanselage, Santha D. Chinanonwait, Nipon Kitchakarn, Suravadee Nausien, Johnny Naket, Esau Duc, Thang Ngo Do Manh, Ha Hong, Young S. Cheng, Qin Richards, Jack S. Kusriastuti, Rita Satyagraha, Ari Noviyanti, Rintis Ding, Xavier C. Khan, Wasif Ali Swe Phru, Ching Guoding, Zhu Qi, Gao Kaneko, Akira Miotto, Olivo Nguitragool, Wang Roobsoong, Wanlapa Battle, Katherine Howes, Rosalind E. Roca-Feltrer, Arantxa Duparc, Stephan Bhowmick, Ipsita Pal Kenangalem, Enny Bibit, Jo-Anne Barry, Alyssa Sintasath, David Abeyasinghe, Rabindra Sibley, Carol H. McCarthy, James von Seidlein, Lorenz Baird, J. Kevin Price, Ric N. Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title | Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_full | Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_fullStr | Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_full_unstemmed | Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_short | Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group |
title_sort | challenges for achieving safe and effective radical cure of plasmodium vivax: a round table discussion of the apmen vivax working group |
topic | Meeting Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382417/ https://www.ncbi.nlm.nih.gov/pubmed/28381261 http://dx.doi.org/10.1186/s12936-017-1784-1 |
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