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Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety

The use of growth promoting and therapeutic antibiotics in piglet feed has been a concerning subject over the last few decades because of the risk of generating antimicrobial resistance that could be transferred to humans. As a result, many products have been proposed as potential alternatives to th...

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Autores principales: Pérez-Bosque, Anna, Polo, Javier, Torrallardona, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382520/
https://www.ncbi.nlm.nih.gov/pubmed/28405442
http://dx.doi.org/10.1186/s40813-016-0034-1
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author Pérez-Bosque, Anna
Polo, Javier
Torrallardona, David
author_facet Pérez-Bosque, Anna
Polo, Javier
Torrallardona, David
author_sort Pérez-Bosque, Anna
collection PubMed
description The use of growth promoting and therapeutic antibiotics in piglet feed has been a concerning subject over the last few decades because of the risk of generating antimicrobial resistance that could be transferred to humans. As a result, many products have been proposed as potential alternatives to the use of antibiotics, and among these, spray dried plasma is considered one of the most promising. However, there have been concerns about its biosafety, particularly during periods of emergence or re-emergence of swine diseases in different regions of the world, such as the recent porcine epidemic diarrhea virus outbreak in North America. The objectives of this paper are to review recent publications about the use of spray dried plasma as an alternative to antibiotics in weaned pig diets, the possible mechanisms of action of spray dried plasma, and the existing evidence related to the biosafety of spray dried animal plasma. Particular attention is given to studies in which spray dried plasma has been directly compared to antibiotics or other alternative antimicrobial products. Several studies on the possible modes of action for spray dried plasma, such as preservation of gut barrier function or modulation of the immune response, are also reviewed. Finally, the paper focuses on the review of the existing studies on the risks of disease transmission with the use of spray dried plasma from porcine origin. Overall, spray dried plasma is a promising alternative to in-feed antimicrobials for piglets, particularly during the early stages of the post-weaning phase. Additionally, there is enough evidence to support that commercial spray dried porcine plasma is a safe product for pigs.
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spelling pubmed-53825202017-04-12 Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety Pérez-Bosque, Anna Polo, Javier Torrallardona, David Porcine Health Manag Review The use of growth promoting and therapeutic antibiotics in piglet feed has been a concerning subject over the last few decades because of the risk of generating antimicrobial resistance that could be transferred to humans. As a result, many products have been proposed as potential alternatives to the use of antibiotics, and among these, spray dried plasma is considered one of the most promising. However, there have been concerns about its biosafety, particularly during periods of emergence or re-emergence of swine diseases in different regions of the world, such as the recent porcine epidemic diarrhea virus outbreak in North America. The objectives of this paper are to review recent publications about the use of spray dried plasma as an alternative to antibiotics in weaned pig diets, the possible mechanisms of action of spray dried plasma, and the existing evidence related to the biosafety of spray dried animal plasma. Particular attention is given to studies in which spray dried plasma has been directly compared to antibiotics or other alternative antimicrobial products. Several studies on the possible modes of action for spray dried plasma, such as preservation of gut barrier function or modulation of the immune response, are also reviewed. Finally, the paper focuses on the review of the existing studies on the risks of disease transmission with the use of spray dried plasma from porcine origin. Overall, spray dried plasma is a promising alternative to in-feed antimicrobials for piglets, particularly during the early stages of the post-weaning phase. Additionally, there is enough evidence to support that commercial spray dried porcine plasma is a safe product for pigs. BioMed Central 2016-07-23 /pmc/articles/PMC5382520/ /pubmed/28405442 http://dx.doi.org/10.1186/s40813-016-0034-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Pérez-Bosque, Anna
Polo, Javier
Torrallardona, David
Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
title Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
title_full Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
title_fullStr Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
title_full_unstemmed Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
title_short Spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
title_sort spray dried plasma as an alternative to antibiotics in piglet feeds, mode of action and biosafety
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382520/
https://www.ncbi.nlm.nih.gov/pubmed/28405442
http://dx.doi.org/10.1186/s40813-016-0034-1
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