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Progress of antibody-based inhibitors of the HGF–cMET axis in cancer therapy

Dysregulated receptor tyrosine kinase signaling in human cancer cells leads to tumor progression, invasion and metastasis. The receptor tyrosine kinase cMET is frequently overexpressed in cancer tissue, and activation of cMET signaling is related to drug resistance and the processes of carcinogenesi...

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Detalles Bibliográficos
Autores principales: Kim, Ki-Hyun, Kim, Hyori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382561/
https://www.ncbi.nlm.nih.gov/pubmed/28336955
http://dx.doi.org/10.1038/emm.2017.17