Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

[Image: see text] The replicative polymerases cannot accommodate distortions to the native DNA sequence such as modifications (lesions) to the native template bases from exposure to reactive metabolites and environmental mutagens. Consequently, DNA synthesis on an afflicted template abruptly stops u...

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Detalles Bibliográficos
Autores principales: Hedglin, Mark, Benkovic, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382571/
https://www.ncbi.nlm.nih.gov/pubmed/28177605
http://dx.doi.org/10.1021/acs.biochem.6b01213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382571/
https://www.ncbi.nlm.nih.gov/pubmed/28177605
http://dx.doi.org/10.1021/acs.biochem.6b01213

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