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Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA
[Image: see text] The replicative polymerases cannot accommodate distortions to the native DNA sequence such as modifications (lesions) to the native template bases from exposure to reactive metabolites and environmental mutagens. Consequently, DNA synthesis on an afflicted template abruptly stops u...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382571/ https://www.ncbi.nlm.nih.gov/pubmed/28177605 http://dx.doi.org/10.1021/acs.biochem.6b01213 |