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Immunological parameters in girls with Turner syndrome
Disturbances in the immune system has been described in Turner syndrome, with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome (45, X), thyroiditis being the most common. Besides the ty...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538258/ https://www.ncbi.nlm.nih.gov/pubmed/15563731 http://dx.doi.org/10.1186/1477-5751-3-6 |
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author | Stenberg, Annika E Sylvén, Lisskulla Magnusson, Carl GM Hultcrantz, Malou |
author_facet | Stenberg, Annika E Sylvén, Lisskulla Magnusson, Carl GM Hultcrantz, Malou |
author_sort | Stenberg, Annika E |
collection | PubMed |
description | Disturbances in the immune system has been described in Turner syndrome, with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome (45, X), thyroiditis being the most common. Besides the typical features of Turner syndrome (short stature, failure to enter puberty spontaneously and infertility due to ovarian insufficiency) ear problems are common (recurrent otitis media and progressive sensorineural hearing disorder). Levels of IgG, IgA, IgM, IgD and the four IgG subclasses as well as T- and B-lymphocyte subpopulations were investigated in 15 girls with Turners syndrome to examine whether an immunodeficiency may be the cause of their high incidence of otitis media. No major immunological deficiency was found that could explain the increased incidence of otitis media in the young Turner girls. |
format | Text |
id | pubmed-538258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-5382582004-12-19 Immunological parameters in girls with Turner syndrome Stenberg, Annika E Sylvén, Lisskulla Magnusson, Carl GM Hultcrantz, Malou J Negat Results Biomed Research Disturbances in the immune system has been described in Turner syndrome, with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome (45, X), thyroiditis being the most common. Besides the typical features of Turner syndrome (short stature, failure to enter puberty spontaneously and infertility due to ovarian insufficiency) ear problems are common (recurrent otitis media and progressive sensorineural hearing disorder). Levels of IgG, IgA, IgM, IgD and the four IgG subclasses as well as T- and B-lymphocyte subpopulations were investigated in 15 girls with Turners syndrome to examine whether an immunodeficiency may be the cause of their high incidence of otitis media. No major immunological deficiency was found that could explain the increased incidence of otitis media in the young Turner girls. BioMed Central 2004-11-25 /pmc/articles/PMC538258/ /pubmed/15563731 http://dx.doi.org/10.1186/1477-5751-3-6 Text en Copyright © 2004 Stenberg et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Stenberg, Annika E Sylvén, Lisskulla Magnusson, Carl GM Hultcrantz, Malou Immunological parameters in girls with Turner syndrome |
title | Immunological parameters in girls with Turner syndrome |
title_full | Immunological parameters in girls with Turner syndrome |
title_fullStr | Immunological parameters in girls with Turner syndrome |
title_full_unstemmed | Immunological parameters in girls with Turner syndrome |
title_short | Immunological parameters in girls with Turner syndrome |
title_sort | immunological parameters in girls with turner syndrome |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538258/ https://www.ncbi.nlm.nih.gov/pubmed/15563731 http://dx.doi.org/10.1186/1477-5751-3-6 |
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