Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru

The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living in Caraz, Peru, during a clinical trial of treatment for b...

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Autores principales: Mullins, Kristin E., Hang, Jun, Clifford, Robert J., Onmus-Leone, Fatma, Yang, Yu, Jiang, Ju, Leguia, Mariana, Kasper, Matthew R., Maguina, Ciro, Lesho, Emil P., Jarman, Richard G., Richards, Allen, Blazes, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382735/
https://www.ncbi.nlm.nih.gov/pubmed/28221130
http://dx.doi.org/10.3201/eid2303.161476
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author Mullins, Kristin E.
Hang, Jun
Clifford, Robert J.
Onmus-Leone, Fatma
Yang, Yu
Jiang, Ju
Leguia, Mariana
Kasper, Matthew R.
Maguina, Ciro
Lesho, Emil P.
Jarman, Richard G.
Richards, Allen
Blazes, David
author_facet Mullins, Kristin E.
Hang, Jun
Clifford, Robert J.
Onmus-Leone, Fatma
Yang, Yu
Jiang, Ju
Leguia, Mariana
Kasper, Matthew R.
Maguina, Ciro
Lesho, Emil P.
Jarman, Richard G.
Richards, Allen
Blazes, David
author_sort Mullins, Kristin E.
collection PubMed
description The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living in Caraz, Peru, during a clinical trial of treatment for bartonellosis. Three B. ancashensis strains were analyzed by using whole-genome restriction mapping and high-throughput pyrosequencing. Genome-wide comparative analysis of Bartonella species showed that B. ancashensis has features seen in modern and ancient lineages of Bartonella species and is more related to B. bacilliformis. The divergence between B. ancashensis and B. bacilliformis is much greater than what is seen between known Bartonella genetic lineages. In addition, B. ancashensis contains type IV secretion system proteins, which are not present in B. bacilliformis. Whole-genome analysis indicates that B. ancashensis might represent a distinct Bartonella lineage phylogenetically related to B. bacilliformis.
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spelling pubmed-53827352017-04-06 Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru Mullins, Kristin E. Hang, Jun Clifford, Robert J. Onmus-Leone, Fatma Yang, Yu Jiang, Ju Leguia, Mariana Kasper, Matthew R. Maguina, Ciro Lesho, Emil P. Jarman, Richard G. Richards, Allen Blazes, David Emerg Infect Dis Research The genus Bartonella contains >40 species, and an increasing number of these Bartonella species are being implicated in human disease. One such pathogen is Bartonella ancashensis, which was isolated in blood samples from 2 patients living in Caraz, Peru, during a clinical trial of treatment for bartonellosis. Three B. ancashensis strains were analyzed by using whole-genome restriction mapping and high-throughput pyrosequencing. Genome-wide comparative analysis of Bartonella species showed that B. ancashensis has features seen in modern and ancient lineages of Bartonella species and is more related to B. bacilliformis. The divergence between B. ancashensis and B. bacilliformis is much greater than what is seen between known Bartonella genetic lineages. In addition, B. ancashensis contains type IV secretion system proteins, which are not present in B. bacilliformis. Whole-genome analysis indicates that B. ancashensis might represent a distinct Bartonella lineage phylogenetically related to B. bacilliformis. Centers for Disease Control and Prevention 2017-03 /pmc/articles/PMC5382735/ /pubmed/28221130 http://dx.doi.org/10.3201/eid2303.161476 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Mullins, Kristin E.
Hang, Jun
Clifford, Robert J.
Onmus-Leone, Fatma
Yang, Yu
Jiang, Ju
Leguia, Mariana
Kasper, Matthew R.
Maguina, Ciro
Lesho, Emil P.
Jarman, Richard G.
Richards, Allen
Blazes, David
Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
title Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
title_full Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
title_fullStr Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
title_full_unstemmed Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
title_short Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru
title_sort whole-genome analysis of bartonella ancashensis, a novel pathogen causing verruga peruana, rural ancash region, peru
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382735/
https://www.ncbi.nlm.nih.gov/pubmed/28221130
http://dx.doi.org/10.3201/eid2303.161476
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