pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia

Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. A...

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Autores principales: Allana, Salim, Shashkina, Elena, Mathema, Barun, Bablishvili, Nino, Tukvadze, Nestani, Shah, N. Sarita, Kempker, Russell R., Blumberg, Henry M., Moodley, Pravi, Mlisana, Koleka, Brust, James C.M., Gandhi, Neel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382742/
https://www.ncbi.nlm.nih.gov/pubmed/28221108
http://dx.doi.org/10.3201/eid2303.161034
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author Allana, Salim
Shashkina, Elena
Mathema, Barun
Bablishvili, Nino
Tukvadze, Nestani
Shah, N. Sarita
Kempker, Russell R.
Blumberg, Henry M.
Moodley, Pravi
Mlisana, Koleka
Brust, James C.M.
Gandhi, Neel R.
author_facet Allana, Salim
Shashkina, Elena
Mathema, Barun
Bablishvili, Nino
Tukvadze, Nestani
Shah, N. Sarita
Kempker, Russell R.
Blumberg, Henry M.
Moodley, Pravi
Mlisana, Koleka
Brust, James C.M.
Gandhi, Neel R.
author_sort Allana, Salim
collection PubMed
description Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.
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spelling pubmed-53827422017-04-06 pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia Allana, Salim Shashkina, Elena Mathema, Barun Bablishvili, Nino Tukvadze, Nestani Shah, N. Sarita Kempker, Russell R. Blumberg, Henry M. Moodley, Pravi Mlisana, Koleka Brust, James C.M. Gandhi, Neel R. Emerg Infect Dis Dispatch Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis. Centers for Disease Control and Prevention 2017-03 /pmc/articles/PMC5382742/ /pubmed/28221108 http://dx.doi.org/10.3201/eid2303.161034 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Allana, Salim
Shashkina, Elena
Mathema, Barun
Bablishvili, Nino
Tukvadze, Nestani
Shah, N. Sarita
Kempker, Russell R.
Blumberg, Henry M.
Moodley, Pravi
Mlisana, Koleka
Brust, James C.M.
Gandhi, Neel R.
pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
title pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
title_full pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
title_fullStr pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
title_full_unstemmed pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
title_short pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
title_sort pnca gene mutations associated with pyrazinamide resistance in drug-resistant tuberculosis, south africa and georgia
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382742/
https://www.ncbi.nlm.nih.gov/pubmed/28221108
http://dx.doi.org/10.3201/eid2303.161034
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