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Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009–2015, we performed a popula...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382749/ https://www.ncbi.nlm.nih.gov/pubmed/28221133 http://dx.doi.org/10.3201/eid2303.161571 |
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author | Seto, Junji Wada, Takayuki Suzuki, Yu Ikeda, Tatsuya Mizuta, Katsumi Yamamoto, Taro Ahiko, Tadayuki |
author_facet | Seto, Junji Wada, Takayuki Suzuki, Yu Ikeda, Tatsuya Mizuta, Katsumi Yamamoto, Taro Ahiko, Tadayuki |
author_sort | Seto, Junji |
collection | PubMed |
description | In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009–2015, we performed a population-based TB investigation in Yamagata Prefecture, Japan, using in-depth contact tracing and 24-loci variable-number tandem-repeat typing optimized for Beijing family M. tuberculosis strains. We analyzed 494 strains, of which 387 (78.3%) were derived from elderly patients. Recent transmission with an epidemiologic link was confirmed in 22 clusters (70 cases). In 17 (77.3%) clusters, the source patient was elderly; 11 (64.7%) of the 17 clusters occurred in a hospital or nursing home. In this setting, the increase in TB cases was associated with M. tuberculosis transmissions from elderly persons. Prevention of transmission in places where elderly persons gather will be an effective strategy for decreasing TB incidence among predominantly elderly populations. |
format | Online Article Text |
id | pubmed-5382749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-53827492017-04-06 Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 Seto, Junji Wada, Takayuki Suzuki, Yu Ikeda, Tatsuya Mizuta, Katsumi Yamamoto, Taro Ahiko, Tadayuki Emerg Infect Dis Research In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009–2015, we performed a population-based TB investigation in Yamagata Prefecture, Japan, using in-depth contact tracing and 24-loci variable-number tandem-repeat typing optimized for Beijing family M. tuberculosis strains. We analyzed 494 strains, of which 387 (78.3%) were derived from elderly patients. Recent transmission with an epidemiologic link was confirmed in 22 clusters (70 cases). In 17 (77.3%) clusters, the source patient was elderly; 11 (64.7%) of the 17 clusters occurred in a hospital or nursing home. In this setting, the increase in TB cases was associated with M. tuberculosis transmissions from elderly persons. Prevention of transmission in places where elderly persons gather will be an effective strategy for decreasing TB incidence among predominantly elderly populations. Centers for Disease Control and Prevention 2017-03 /pmc/articles/PMC5382749/ /pubmed/28221133 http://dx.doi.org/10.3201/eid2303.161571 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Seto, Junji Wada, Takayuki Suzuki, Yu Ikeda, Tatsuya Mizuta, Katsumi Yamamoto, Taro Ahiko, Tadayuki Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 |
title | Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 |
title_full | Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 |
title_fullStr | Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 |
title_full_unstemmed | Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 |
title_short | Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 |
title_sort | mycobacterium tuberculosis transmission among elderly persons, yamagata prefecture, japan, 2009–2015 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382749/ https://www.ncbi.nlm.nih.gov/pubmed/28221133 http://dx.doi.org/10.3201/eid2303.161571 |
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