Cargando…

Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015

In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009–2015, we performed a popula...

Descripción completa

Detalles Bibliográficos
Autores principales: Seto, Junji, Wada, Takayuki, Suzuki, Yu, Ikeda, Tatsuya, Mizuta, Katsumi, Yamamoto, Taro, Ahiko, Tadayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382749/
https://www.ncbi.nlm.nih.gov/pubmed/28221133
http://dx.doi.org/10.3201/eid2303.161571
_version_ 1782520160398082048
author Seto, Junji
Wada, Takayuki
Suzuki, Yu
Ikeda, Tatsuya
Mizuta, Katsumi
Yamamoto, Taro
Ahiko, Tadayuki
author_facet Seto, Junji
Wada, Takayuki
Suzuki, Yu
Ikeda, Tatsuya
Mizuta, Katsumi
Yamamoto, Taro
Ahiko, Tadayuki
author_sort Seto, Junji
collection PubMed
description In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009–2015, we performed a population-based TB investigation in Yamagata Prefecture, Japan, using in-depth contact tracing and 24-loci variable-number tandem-repeat typing optimized for Beijing family M. tuberculosis strains. We analyzed 494 strains, of which 387 (78.3%) were derived from elderly patients. Recent transmission with an epidemiologic link was confirmed in 22 clusters (70 cases). In 17 (77.3%) clusters, the source patient was elderly; 11 (64.7%) of the 17 clusters occurred in a hospital or nursing home. In this setting, the increase in TB cases was associated with M. tuberculosis transmissions from elderly persons. Prevention of transmission in places where elderly persons gather will be an effective strategy for decreasing TB incidence among predominantly elderly populations.
format Online
Article
Text
id pubmed-5382749
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-53827492017-04-06 Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015 Seto, Junji Wada, Takayuki Suzuki, Yu Ikeda, Tatsuya Mizuta, Katsumi Yamamoto, Taro Ahiko, Tadayuki Emerg Infect Dis Research In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009–2015, we performed a population-based TB investigation in Yamagata Prefecture, Japan, using in-depth contact tracing and 24-loci variable-number tandem-repeat typing optimized for Beijing family M. tuberculosis strains. We analyzed 494 strains, of which 387 (78.3%) were derived from elderly patients. Recent transmission with an epidemiologic link was confirmed in 22 clusters (70 cases). In 17 (77.3%) clusters, the source patient was elderly; 11 (64.7%) of the 17 clusters occurred in a hospital or nursing home. In this setting, the increase in TB cases was associated with M. tuberculosis transmissions from elderly persons. Prevention of transmission in places where elderly persons gather will be an effective strategy for decreasing TB incidence among predominantly elderly populations. Centers for Disease Control and Prevention 2017-03 /pmc/articles/PMC5382749/ /pubmed/28221133 http://dx.doi.org/10.3201/eid2303.161571 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Seto, Junji
Wada, Takayuki
Suzuki, Yu
Ikeda, Tatsuya
Mizuta, Katsumi
Yamamoto, Taro
Ahiko, Tadayuki
Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
title Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
title_full Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
title_fullStr Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
title_full_unstemmed Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
title_short Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009–2015
title_sort mycobacterium tuberculosis transmission among elderly persons, yamagata prefecture, japan, 2009–2015
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382749/
https://www.ncbi.nlm.nih.gov/pubmed/28221133
http://dx.doi.org/10.3201/eid2303.161571
work_keys_str_mv AT setojunji mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015
AT wadatakayuki mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015
AT suzukiyu mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015
AT ikedatatsuya mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015
AT mizutakatsumi mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015
AT yamamototaro mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015
AT ahikotadayuki mycobacteriumtuberculosistransmissionamongelderlypersonsyamagataprefecturejapan20092015