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New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo

Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-...

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Autores principales: Malm, Sven, Linguissi, Laure S. Ghoma, Tekwu, Emmanuel M., Vouvoungui, Jeannhey C., Kohl, Thomas A., Beckert, Patrick, Sidibe, Anissa, Rüsch-Gerdes, Sabine, Madzou-Laboum, Igor K., Kwedi, Sylvie, Penlap Beng, Véronique, Frank, Matthias, Ntoumi, Francine, Niemann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382753/
https://www.ncbi.nlm.nih.gov/pubmed/28221129
http://dx.doi.org/10.3201/eid2303.160679
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author Malm, Sven
Linguissi, Laure S. Ghoma
Tekwu, Emmanuel M.
Vouvoungui, Jeannhey C.
Kohl, Thomas A.
Beckert, Patrick
Sidibe, Anissa
Rüsch-Gerdes, Sabine
Madzou-Laboum, Igor K.
Kwedi, Sylvie
Penlap Beng, Véronique
Frank, Matthias
Ntoumi, Francine
Niemann, Stefan
author_facet Malm, Sven
Linguissi, Laure S. Ghoma
Tekwu, Emmanuel M.
Vouvoungui, Jeannhey C.
Kohl, Thomas A.
Beckert, Patrick
Sidibe, Anissa
Rüsch-Gerdes, Sabine
Madzou-Laboum, Igor K.
Kwedi, Sylvie
Penlap Beng, Véronique
Frank, Matthias
Ntoumi, Francine
Niemann, Stefan
author_sort Malm, Sven
collection PubMed
description Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-genome sequencing, we phylogenetically characterized 74 MTBC isolates from Brazzaville, the capital of Congo. The diversity of the study population was high; most strains belonged to the Euro-American lineage, which split into Latin American Mediterranean, Uganda I, Uganda II, Haarlem, X type, and a new dominant sublineage named Congo type (n = 26). Thirty strains were grouped in 5 clusters (each within 12 single-nucleotide polymorphisms), from which 23 belonged to the Congo type. High cluster rates and low genomic diversity indicate recent emergence and transmission of the Congo type, a new Euro-American sublineage of MTBC.
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spelling pubmed-53827532017-04-06 New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo Malm, Sven Linguissi, Laure S. Ghoma Tekwu, Emmanuel M. Vouvoungui, Jeannhey C. Kohl, Thomas A. Beckert, Patrick Sidibe, Anissa Rüsch-Gerdes, Sabine Madzou-Laboum, Igor K. Kwedi, Sylvie Penlap Beng, Véronique Frank, Matthias Ntoumi, Francine Niemann, Stefan Emerg Infect Dis Research Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-genome sequencing, we phylogenetically characterized 74 MTBC isolates from Brazzaville, the capital of Congo. The diversity of the study population was high; most strains belonged to the Euro-American lineage, which split into Latin American Mediterranean, Uganda I, Uganda II, Haarlem, X type, and a new dominant sublineage named Congo type (n = 26). Thirty strains were grouped in 5 clusters (each within 12 single-nucleotide polymorphisms), from which 23 belonged to the Congo type. High cluster rates and low genomic diversity indicate recent emergence and transmission of the Congo type, a new Euro-American sublineage of MTBC. Centers for Disease Control and Prevention 2017-03 /pmc/articles/PMC5382753/ /pubmed/28221129 http://dx.doi.org/10.3201/eid2303.160679 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Malm, Sven
Linguissi, Laure S. Ghoma
Tekwu, Emmanuel M.
Vouvoungui, Jeannhey C.
Kohl, Thomas A.
Beckert, Patrick
Sidibe, Anissa
Rüsch-Gerdes, Sabine
Madzou-Laboum, Igor K.
Kwedi, Sylvie
Penlap Beng, Véronique
Frank, Matthias
Ntoumi, Francine
Niemann, Stefan
New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
title New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
title_full New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
title_fullStr New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
title_full_unstemmed New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
title_short New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
title_sort new mycobacterium tuberculosis complex sublineage, brazzaville, congo
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382753/
https://www.ncbi.nlm.nih.gov/pubmed/28221129
http://dx.doi.org/10.3201/eid2303.160679
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