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New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo
Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382753/ https://www.ncbi.nlm.nih.gov/pubmed/28221129 http://dx.doi.org/10.3201/eid2303.160679 |
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author | Malm, Sven Linguissi, Laure S. Ghoma Tekwu, Emmanuel M. Vouvoungui, Jeannhey C. Kohl, Thomas A. Beckert, Patrick Sidibe, Anissa Rüsch-Gerdes, Sabine Madzou-Laboum, Igor K. Kwedi, Sylvie Penlap Beng, Véronique Frank, Matthias Ntoumi, Francine Niemann, Stefan |
author_facet | Malm, Sven Linguissi, Laure S. Ghoma Tekwu, Emmanuel M. Vouvoungui, Jeannhey C. Kohl, Thomas A. Beckert, Patrick Sidibe, Anissa Rüsch-Gerdes, Sabine Madzou-Laboum, Igor K. Kwedi, Sylvie Penlap Beng, Véronique Frank, Matthias Ntoumi, Francine Niemann, Stefan |
author_sort | Malm, Sven |
collection | PubMed |
description | Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-genome sequencing, we phylogenetically characterized 74 MTBC isolates from Brazzaville, the capital of Congo. The diversity of the study population was high; most strains belonged to the Euro-American lineage, which split into Latin American Mediterranean, Uganda I, Uganda II, Haarlem, X type, and a new dominant sublineage named Congo type (n = 26). Thirty strains were grouped in 5 clusters (each within 12 single-nucleotide polymorphisms), from which 23 belonged to the Congo type. High cluster rates and low genomic diversity indicate recent emergence and transmission of the Congo type, a new Euro-American sublineage of MTBC. |
format | Online Article Text |
id | pubmed-5382753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-53827532017-04-06 New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo Malm, Sven Linguissi, Laure S. Ghoma Tekwu, Emmanuel M. Vouvoungui, Jeannhey C. Kohl, Thomas A. Beckert, Patrick Sidibe, Anissa Rüsch-Gerdes, Sabine Madzou-Laboum, Igor K. Kwedi, Sylvie Penlap Beng, Véronique Frank, Matthias Ntoumi, Francine Niemann, Stefan Emerg Infect Dis Research Tuberculosis is a leading cause of illness and death in Congo. No data are available about the population structure and transmission dynamics of the Mycobacterium tuberculosis complex strains prevalent in this central Africa country. On the basis of single-nucleotide polymorphisms detected by whole-genome sequencing, we phylogenetically characterized 74 MTBC isolates from Brazzaville, the capital of Congo. The diversity of the study population was high; most strains belonged to the Euro-American lineage, which split into Latin American Mediterranean, Uganda I, Uganda II, Haarlem, X type, and a new dominant sublineage named Congo type (n = 26). Thirty strains were grouped in 5 clusters (each within 12 single-nucleotide polymorphisms), from which 23 belonged to the Congo type. High cluster rates and low genomic diversity indicate recent emergence and transmission of the Congo type, a new Euro-American sublineage of MTBC. Centers for Disease Control and Prevention 2017-03 /pmc/articles/PMC5382753/ /pubmed/28221129 http://dx.doi.org/10.3201/eid2303.160679 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Malm, Sven Linguissi, Laure S. Ghoma Tekwu, Emmanuel M. Vouvoungui, Jeannhey C. Kohl, Thomas A. Beckert, Patrick Sidibe, Anissa Rüsch-Gerdes, Sabine Madzou-Laboum, Igor K. Kwedi, Sylvie Penlap Beng, Véronique Frank, Matthias Ntoumi, Francine Niemann, Stefan New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo |
title | New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo |
title_full | New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo |
title_fullStr | New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo |
title_full_unstemmed | New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo |
title_short | New Mycobacterium tuberculosis Complex Sublineage, Brazzaville, Congo |
title_sort | new mycobacterium tuberculosis complex sublineage, brazzaville, congo |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382753/ https://www.ncbi.nlm.nih.gov/pubmed/28221129 http://dx.doi.org/10.3201/eid2303.160679 |
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