Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown–Vialetto disease that is partially rescued by riboflavin

Riboflavin is essential in numerous cellular oxidation/reduction reactions but is not synthesized by mammalian cells. Riboflavin absorption occurs through the human riboflavin transporters RFVT1 and RFVT3 in the intestine and RFVT2 in the brain. Mutations in these genes are causative for the Brown–V...

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Detalles Bibliográficos
Autores principales: Rizzo, Federica, Ramirez, Agnese, Compagnucci, Claudia, Salani, Sabrina, Melzi, Valentina, Bordoni, Andreina, Fortunato, Francesco, Niceforo, Alessia, Bresolin, Nereo, Comi, Giacomo P., Bertini, Enrico, Nizzardo, Monica, Corti, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382781/
https://www.ncbi.nlm.nih.gov/pubmed/28382968
http://dx.doi.org/10.1038/srep46271

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