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Production and physiological role of NO in the oral cavity

Nitric oxide (NO) is a free radical which is produced from a wide variety of cells and tissues in the human body. NO is involved in the regulation of many physiological processes, such as vascular relaxation, neurotransmission, immune regulation, and cell death. NO is generated by nitric oxide synth...

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Autores principales: Ambe, Kimiharu, Watanabe, Hiroki, Takahashi, Shinya, Nakagawa, Toshihiro, Sasaki, Junzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382787/
https://www.ncbi.nlm.nih.gov/pubmed/28408951
http://dx.doi.org/10.1016/j.jdsr.2015.08.001
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author Ambe, Kimiharu
Watanabe, Hiroki
Takahashi, Shinya
Nakagawa, Toshihiro
Sasaki, Junzo
author_facet Ambe, Kimiharu
Watanabe, Hiroki
Takahashi, Shinya
Nakagawa, Toshihiro
Sasaki, Junzo
author_sort Ambe, Kimiharu
collection PubMed
description Nitric oxide (NO) is a free radical which is produced from a wide variety of cells and tissues in the human body. NO is involved in the regulation of many physiological processes, such as vascular relaxation, neurotransmission, immune regulation, and cell death. NO is generated by nitric oxide synthase (NOS), which has three identified isoforms: neuronal type NOS (nNOS), endothelial type NOS (eNOS), and inducible type NOS (iNOS). Different isoforms are expressed depending on the organs, tissues, and cells, and investigation of the types and functions of enzymes expressed in various tissues is underway. The oral cavity is a space in which marked changes have been detected in NO levels, and each tissue is constantly influenced by NO. NO is a component of saliva and is produced by oral bacteria in the oral cavity and released by NOS expressed in oral mucosa. NOS isoforms expressed under normal conditions differ among the oral organs. In addition, the overexpression of NOS was involved in carcinogenesis and tumor growth progression. This review summarized the expression of NOS and functions of NO in oral cavity organs, and their roles in diseases and the influences of treatments.
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spelling pubmed-53827872017-04-13 Production and physiological role of NO in the oral cavity Ambe, Kimiharu Watanabe, Hiroki Takahashi, Shinya Nakagawa, Toshihiro Sasaki, Junzo Jpn Dent Sci Rev Review Article Nitric oxide (NO) is a free radical which is produced from a wide variety of cells and tissues in the human body. NO is involved in the regulation of many physiological processes, such as vascular relaxation, neurotransmission, immune regulation, and cell death. NO is generated by nitric oxide synthase (NOS), which has three identified isoforms: neuronal type NOS (nNOS), endothelial type NOS (eNOS), and inducible type NOS (iNOS). Different isoforms are expressed depending on the organs, tissues, and cells, and investigation of the types and functions of enzymes expressed in various tissues is underway. The oral cavity is a space in which marked changes have been detected in NO levels, and each tissue is constantly influenced by NO. NO is a component of saliva and is produced by oral bacteria in the oral cavity and released by NOS expressed in oral mucosa. NOS isoforms expressed under normal conditions differ among the oral organs. In addition, the overexpression of NOS was involved in carcinogenesis and tumor growth progression. This review summarized the expression of NOS and functions of NO in oral cavity organs, and their roles in diseases and the influences of treatments. Elsevier 2016-02 2015-09-11 /pmc/articles/PMC5382787/ /pubmed/28408951 http://dx.doi.org/10.1016/j.jdsr.2015.08.001 Text en © 2015 Japanese Association for Dental Science. Published by Elsevier Ltd. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Ambe, Kimiharu
Watanabe, Hiroki
Takahashi, Shinya
Nakagawa, Toshihiro
Sasaki, Junzo
Production and physiological role of NO in the oral cavity
title Production and physiological role of NO in the oral cavity
title_full Production and physiological role of NO in the oral cavity
title_fullStr Production and physiological role of NO in the oral cavity
title_full_unstemmed Production and physiological role of NO in the oral cavity
title_short Production and physiological role of NO in the oral cavity
title_sort production and physiological role of no in the oral cavity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382787/
https://www.ncbi.nlm.nih.gov/pubmed/28408951
http://dx.doi.org/10.1016/j.jdsr.2015.08.001
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