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The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations

Chronic kidney disease (CKD) is a common clinical condition with significant adverse consequences for the patient and it is recognized as a significant public health problem. The role of laboratory medicine in diagnosis and management of CKD is of great importance: the diagnosis and staging are base...

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Autores principales: Biljak, Vanja Radišić, Honović, Lorena, Matica, Jasminka, Krešić, Branka, Vojak, Sanela Šimić
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Society of Medical Biochemistry and Laboratory Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382859/
https://www.ncbi.nlm.nih.gov/pubmed/28392738
http://dx.doi.org/10.11613/BM.2017.019
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author Biljak, Vanja Radišić
Honović, Lorena
Matica, Jasminka
Krešić, Branka
Vojak, Sanela Šimić
author_facet Biljak, Vanja Radišić
Honović, Lorena
Matica, Jasminka
Krešić, Branka
Vojak, Sanela Šimić
author_sort Biljak, Vanja Radišić
collection PubMed
description Chronic kidney disease (CKD) is a common clinical condition with significant adverse consequences for the patient and it is recognized as a significant public health problem. The role of laboratory medicine in diagnosis and management of CKD is of great importance: the diagnosis and staging are based on estimation of glomerular filtration rate (eGFR) and assessment of albuminuria (or proteinuria). Therefore, the joint working group of the Croatian society of medical biochemistry and laboratory medicine and Croatian chamber of medical biochemists for laboratory diagnostics in CKD issued this national recommendation regarding laboratory diagnostics of CKD.
Key factors for laboratories implementing the national guidelines for the diagnosis and management of CKD are:
1. Ensure good communication between laboratory professionals and clinicians, such as nephrologists or specialists in general/family medicine,
2. Ensure all patients are provided with the same availability of laboratory diagnostics,
3. Ensure creatinine assays are traceable to isotope dilution mass spectrometry (IDMS) method and have minimal bias and acceptable imprecision,
4. Select the appropriate GFR estimating formula. Recommended equation is the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD – EPI) equation,
5. In reporting the key laboratory tests (creatinine, eGFR, urine albumin-to-creatinine ratio, urine protein-to-creatinine ratio) use the appropriate reporting units,
6. Provide adequate information on limitations of creatinine measurement.
The manuscript has been organized to identify critical points in laboratory tests used in basic laboratory diagnostics of CKD and is based on the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.
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spelling pubmed-53828592017-04-07 The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations Biljak, Vanja Radišić Honović, Lorena Matica, Jasminka Krešić, Branka Vojak, Sanela Šimić Biochem Med (Zagreb) Review Chronic kidney disease (CKD) is a common clinical condition with significant adverse consequences for the patient and it is recognized as a significant public health problem. The role of laboratory medicine in diagnosis and management of CKD is of great importance: the diagnosis and staging are based on estimation of glomerular filtration rate (eGFR) and assessment of albuminuria (or proteinuria). Therefore, the joint working group of the Croatian society of medical biochemistry and laboratory medicine and Croatian chamber of medical biochemists for laboratory diagnostics in CKD issued this national recommendation regarding laboratory diagnostics of CKD.
Key factors for laboratories implementing the national guidelines for the diagnosis and management of CKD are:
1. Ensure good communication between laboratory professionals and clinicians, such as nephrologists or specialists in general/family medicine,
2. Ensure all patients are provided with the same availability of laboratory diagnostics,
3. Ensure creatinine assays are traceable to isotope dilution mass spectrometry (IDMS) method and have minimal bias and acceptable imprecision,
4. Select the appropriate GFR estimating formula. Recommended equation is the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD – EPI) equation,
5. In reporting the key laboratory tests (creatinine, eGFR, urine albumin-to-creatinine ratio, urine protein-to-creatinine ratio) use the appropriate reporting units,
6. Provide adequate information on limitations of creatinine measurement.
The manuscript has been organized to identify critical points in laboratory tests used in basic laboratory diagnostics of CKD and is based on the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Croatian Society of Medical Biochemistry and Laboratory Medicine 2017-02-15 2017-02-15 /pmc/articles/PMC5382859/ /pubmed/28392738 http://dx.doi.org/10.11613/BM.2017.019 Text en
spellingShingle Review
Biljak, Vanja Radišić
Honović, Lorena
Matica, Jasminka
Krešić, Branka
Vojak, Sanela Šimić
The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
title The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
title_full The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
title_fullStr The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
title_full_unstemmed The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
title_short The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
title_sort role of laboratory testing in detection and classification of chronic kidney disease: national recommendations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382859/
https://www.ncbi.nlm.nih.gov/pubmed/28392738
http://dx.doi.org/10.11613/BM.2017.019
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