Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells

Activation-induced cytidine deaminase (AID) is a B-cell specific enzyme that targets immunoglobulin (Ig) genes to initiate class switch recombination (CSR) and somatic hypermutation (SHM)(1). Through off-target activity, however, AID has a much broader impact on genomic instability by initiating onc...

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Detalles Bibliográficos
Autores principales: Compagno, Mara, Wang, Qi, Pighi, Chiara, Cheong, Taek-Chin, Meng, Fei-Long, Poggio, Teresa, Yeap, Leng-Siew, Karaca, Elif, Blasco, Rafael B., Langellotto, Fernanda, Ambrogio, Chiara, Voena, Claudia, Wiestner, Adrian, Kasar, Siddha N., Brown, Jennifer R., Sun, Jing, Wu, Catherine J., Gostissa, Monica, Alt, Frederick W., Chiarle, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382874/
https://www.ncbi.nlm.nih.gov/pubmed/28199309
http://dx.doi.org/10.1038/nature21406

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