MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways

Hepatocellular carcinoma (HCC) is the second leading cause of cancer related-death. As a major common regulator of numerous cancer-driving pathways and a unique therapeutic target, the prolyl isomerase Pin1 is overexpressed in a majority of HCCs, whereas the mechanism underlying Pin1 overexpression...

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Detalles Bibliográficos
Autores principales: Yan, Xingxue, Zhu, Zhendong, Xu, Shenmin, Yang, Li-nan, Liao, Xin-Hua, Zheng, Min, Yang, Dayun, Wang, Jichuang, Chen, Dongmei, Wang, Long, Liu, Xiaolong, Liu, Jingfeng, Chen, Ruey-Hwa, Zhen Zhou, Xiao, Ping Lu, Kun, Liu, Hekun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382892/
https://www.ncbi.nlm.nih.gov/pubmed/28383568
http://dx.doi.org/10.1038/srep45915

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