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Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations

KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate I(Ks), the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential. Two KCNQ1 gain-of-function mutations that cause a genetic form of atrial fibrillatio...

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Detalles Bibliográficos
Autores principales:	Peng, Gary, Barro-Soria, Rene, Sampson, Kevin J., Larsson, H. Peter, Kass, Robert S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382920/ https://www.ncbi.nlm.nih.gov/pubmed/28383569 http://dx.doi.org/10.1038/srep45911

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