Operationalizing compensation over time in neurodegenerative disease

In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al. present two mathematical models of compensation over time and their operationalisation for neuroimaging.

Detalles Bibliográficos
Autores principales: Gregory, Sarah, Long, Jeffrey D., Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Papoutsi, Marina, Mills, James A., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A. C., Stout, Julie C., Scahill, Rachael I., Langbehn, Douglas R., Tabrizi, Sarah J., Rees, Geraint
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Dorsal column
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382953/
https://www.ncbi.nlm.nih.gov/pubmed/28334888
http://dx.doi.org/10.1093/brain/awx022
Descripción
Sumario:In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al. present two mathematical models of compensation over time and their operationalisation for neuroimaging.

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