Cargando…
The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential co...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383047/ https://www.ncbi.nlm.nih.gov/pubmed/28384171 http://dx.doi.org/10.1371/journal.pone.0174811 |
_version_ | 1782520210832490496 |
---|---|
author | Hernandes, Fabiana Rodrigues Canziani, Maria Eugênia Fernandes Barreto, Fellype Carvalho Santos, Rodrigo Oliveira Moreira, Valéria de Melo Rochitte, Carlos Eduardo Carvalho, Aluizio Barbosa |
author_facet | Hernandes, Fabiana Rodrigues Canziani, Maria Eugênia Fernandes Barreto, Fellype Carvalho Santos, Rodrigo Oliveira Moreira, Valéria de Melo Rochitte, Carlos Eduardo Carvalho, Aluizio Barbosa |
author_sort | Hernandes, Fabiana Rodrigues |
collection | PubMed |
description | Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTX; bone biopsy was performed at baseline and 12-month. At baseline, all patients had increased PTH levels up to 2500 pg/mL and high turnover bone disease in their bone biopsies. Fourteen (74%) patients had VC. During the follow-up, there was a significant decrease of PTH at 6 and 12-month. At 12-month, 90% of the patients evolved to low turnover bone disease. During the period of the hungry bone syndrome (first 6 months), no change of coronary calcium score was observed. However, calcium score increased significantly thereafter (12(th) month). There was an association between VC progression and the severity of low turnover bone disease. In conclusion, the shift from high to low turnover bone disease after PTX occurs in parallel to VC progression, contributing to the understanding of the complex pathophysiology involving mineral metabolism and cardiovascular disease in hemodialysis patients. |
format | Online Article Text |
id | pubmed-5383047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53830472017-05-03 The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study Hernandes, Fabiana Rodrigues Canziani, Maria Eugênia Fernandes Barreto, Fellype Carvalho Santos, Rodrigo Oliveira Moreira, Valéria de Melo Rochitte, Carlos Eduardo Carvalho, Aluizio Barbosa PLoS One Research Article Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTX; bone biopsy was performed at baseline and 12-month. At baseline, all patients had increased PTH levels up to 2500 pg/mL and high turnover bone disease in their bone biopsies. Fourteen (74%) patients had VC. During the follow-up, there was a significant decrease of PTH at 6 and 12-month. At 12-month, 90% of the patients evolved to low turnover bone disease. During the period of the hungry bone syndrome (first 6 months), no change of coronary calcium score was observed. However, calcium score increased significantly thereafter (12(th) month). There was an association between VC progression and the severity of low turnover bone disease. In conclusion, the shift from high to low turnover bone disease after PTX occurs in parallel to VC progression, contributing to the understanding of the complex pathophysiology involving mineral metabolism and cardiovascular disease in hemodialysis patients. Public Library of Science 2017-04-06 /pmc/articles/PMC5383047/ /pubmed/28384171 http://dx.doi.org/10.1371/journal.pone.0174811 Text en © 2017 Hernandes et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hernandes, Fabiana Rodrigues Canziani, Maria Eugênia Fernandes Barreto, Fellype Carvalho Santos, Rodrigo Oliveira Moreira, Valéria de Melo Rochitte, Carlos Eduardo Carvalho, Aluizio Barbosa The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study |
title | The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study |
title_full | The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study |
title_fullStr | The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study |
title_full_unstemmed | The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study |
title_short | The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study |
title_sort | shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: a 12-month follow-up study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383047/ https://www.ncbi.nlm.nih.gov/pubmed/28384171 http://dx.doi.org/10.1371/journal.pone.0174811 |
work_keys_str_mv | AT hernandesfabianarodrigues theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT canzianimariaeugeniafernandes theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT barretofellypecarvalho theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT santosrodrigooliveira theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT moreiravaleriademelo theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT rochittecarloseduardo theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT carvalhoaluiziobarbosa theshiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT hernandesfabianarodrigues shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT canzianimariaeugeniafernandes shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT barretofellypecarvalho shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT santosrodrigooliveira shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT moreiravaleriademelo shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT rochittecarloseduardo shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy AT carvalhoaluiziobarbosa shiftfromhightolowturnoverbonediseaseafterparathyroidectomyisassociatedwiththeprogressionofvascularcalcificationinhemodialysispatientsa12monthfollowupstudy |