Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation

We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it...

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Detalles Bibliográficos
Autores principales: Ariane, Mostapha, Allouche, Mohamed Hatem, Bussone, Marco, Giacosa, Fausto, Bernard, Frédéric, Barigou, Mostafa, Alexiadis, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383103/
https://www.ncbi.nlm.nih.gov/pubmed/28384341
http://dx.doi.org/10.1371/journal.pone.0174795
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author Ariane, Mostapha
Allouche, Mohamed Hatem
Bussone, Marco
Giacosa, Fausto
Bernard, Frédéric
Barigou, Mostafa
Alexiadis, Alessio
author_facet Ariane, Mostapha
Allouche, Mohamed Hatem
Bussone, Marco
Giacosa, Fausto
Bernard, Frédéric
Barigou, Mostafa
Alexiadis, Alessio
author_sort Ariane, Mostapha
collection PubMed
description We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.
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spelling pubmed-53831032017-05-03 Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation Ariane, Mostapha Allouche, Mohamed Hatem Bussone, Marco Giacosa, Fausto Bernard, Frédéric Barigou, Mostafa Alexiadis, Alessio PLoS One Research Article We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves. Public Library of Science 2017-04-06 /pmc/articles/PMC5383103/ /pubmed/28384341 http://dx.doi.org/10.1371/journal.pone.0174795 Text en © 2017 Ariane et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ariane, Mostapha
Allouche, Mohamed Hatem
Bussone, Marco
Giacosa, Fausto
Bernard, Frédéric
Barigou, Mostafa
Alexiadis, Alessio
Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
title Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
title_full Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
title_fullStr Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
title_full_unstemmed Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
title_short Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation
title_sort discrete multi-physics: a mesh-free model of blood flow in flexible biological valve including solid aggregate formation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383103/
https://www.ncbi.nlm.nih.gov/pubmed/28384341
http://dx.doi.org/10.1371/journal.pone.0174795
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