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Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity
This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of ext...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Neurogastroenterology and Motility
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383113/ https://www.ncbi.nlm.nih.gov/pubmed/28096522 http://dx.doi.org/10.5056/jnm16194 |
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author | Prinz, Philip Stengel, Andreas |
author_facet | Prinz, Philip Stengel, Andreas |
author_sort | Prinz, Philip |
collection | PubMed |
description | This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative—physical activity and pharmacotherapy—treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways. |
format | Online Article Text |
id | pubmed-5383113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society of Neurogastroenterology and Motility |
record_format | MEDLINE/PubMed |
spelling | pubmed-53831132017-04-07 Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity Prinz, Philip Stengel, Andreas J Neurogastroenterol Motil Review This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative—physical activity and pharmacotherapy—treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways. Korean Society of Neurogastroenterology and Motility 2017-04 2017-04-01 /pmc/articles/PMC5383113/ /pubmed/28096522 http://dx.doi.org/10.5056/jnm16194 Text en © 2017 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Prinz, Philip Stengel, Andreas Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity |
title | Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity |
title_full | Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity |
title_fullStr | Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity |
title_full_unstemmed | Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity |
title_short | Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity |
title_sort | control of food intake by gastrointestinal peptides: mechanisms of action and possible modulation in the treatment of obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383113/ https://www.ncbi.nlm.nih.gov/pubmed/28096522 http://dx.doi.org/10.5056/jnm16194 |
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